Adverse Childhood Experiences and Higher Levels of Stress Are Associated With the Co-occurrence of Cancer-Related Cognitive Impairment and Anxiety

被引:2
|
作者
Oppegaard, Kate R. [1 ]
Mayo, Samantha J. [2 ]
Armstrong, Terri S. [3 ]
Kober, Kord M. [1 ]
Anguera, Joaquin [4 ]
Hammer, Marilyn J. [5 ]
Levine, Jon D. [6 ]
Conley, Yvette P. [7 ]
Paul, Steven [1 ]
Cooper, Bruce [8 ]
Miaskowski, Christine [9 ,10 ]
机构
[1] Univ Calif San Francisco, Dept Physiol Nursing, San Francisco, CA 94143 USA
[2] Univ Toronto, Lawrence S Bloomberg Sch Nursing, Toronto, ON, Canada
[3] NCI, Neurooncol Branch, Off Patient Ctr Outcomes Res, Ctr Canc Res, Bethesda, MD USA
[4] Univ Calif San Francisco, Weill Inst Neurosci, Dept Neurol, San Francisco, CA 94143 USA
[5] Dana Farber Canc Inst, Res & Evidence Based Practice, Boston, MA USA
[6] Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA 94143 USA
[7] Univ Pittsburgh, Sch Nursing, Dept Hlth Promot & Dev, Pittsburgh, PA USA
[8] Univ Calif San Francisco, Dept Physiol Nursing, San Francisco, CA 94143 USA
[9] Univ Calif San Francisco, Dept Physiol Nursing & Anesthesia & Perioperat Car, San Francisco, CA 94143 USA
[10] Univ Calif San Francisco, 2 Koret Way N631Y, San Francisco, CA 94143 USA
关键词
Adverse childhood experiences; Anxiety; Chemotherapy; Cognitive impairment; Resilience; Stress; CONNOR-DAVIDSON RESILIENCE; BREAST-CANCER; EVENT SCALE; WOMEN; SURVIVORS; CHEMOTHERAPY; PREVALENCE; VALIDATION; DYSFUNCTION; DEPRESSION;
D O I
10.1016/j.soncn.2023.151513
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: We sought to identify subgroups of patients with distinct joint cancer-related cognitive impairment (CRCI) AND anxiety profiles and evaluate for differences in demographic and clinical characteristics, as well as levels of global stress, cancer-specific stress, cumulative life stress, and resilience.Data Sources: Patients (n = 1332) completed the Attentional Function Index and the Spielberger State Anxiety Inventory six times over two cycles of chemotherapy. Global, cancer-specific, and cumulative life stress and resilience were evaluated using Perceived Stress Scale, Impact of Event Scale-Revised, Life Stressor Checklist Revised, and Connor-Davidson Resilience Scale, respectively. Latent profile analysis was used to identify subgroups of patients with distinct joint CRCI AND anxiety profiles. Differences were evaluated using parametric and nonparametric tests.Results: Three classes were identified (ie, No CRCI and Low Anxiety [57.3%], Moderate CRCI and Moderate Anxiety [34.5%], and High CRCI and High Anxiety [8.2%]). All of the stress measures showed a dose-response effect (ie, as the CRCI AND anxiety profile worsened, scores for all three types of stress increased). The two highest symptom classes reported higher occurrence rates for six specific stressors (eg, emotional abuse, physical abuse, sexual harassment). Conclusions: Findings suggest that higher levels of co-occurring CRCI AND anxiety are associated with some common risk factors, as well as higher levels of stress and lower levels of resilience. Increased knowledge of modifiable risk factors and sources of stress associated with the co-occurrence of these two symptoms will assist clinicians to identify high-risk patients and implement individualized interventions.(c) 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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页数:11
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