Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences

被引：6

作者：

Bentanachs, Roger ^{[1
,2
]}

Blanco, Laia ^{[1
]}

Montesinos, Maria ^{[1
]}

Sala-Vila, Aleix ^{[3
,4
]}

Lazaro, Iolanda ^{[3
,4
]}

Rodriguez-Morato, Jose ^{[4
,5
]}

Sanchez, Rosa Maria ^{[1
,2
,4
]}

Laguna, Juan Carlos ^{[1
,2
,4
]}

Roglans, Nuria ^{[1
,2
,4
]}

Alegret, Marta ^{[1
,2
,4
]}

机构：

[1] Univ Barcelona, Sch Pharm & Food Sci, Dept Pharmacol Toxicol & Therapeut Chem, Barcelona 08028, Spain

[2] Univ Barcelona, Inst Biomed, Barcelona 08028, Spain

[3] IMIM Hosp del Mar Med Res Inst, Barcelona 08003, Spain

[4] Inst Salud Carlos III ISCIII, Spanish Biomed Res Ctr Physiopathol Obes & Nutr CI, Madrid 28029, Spain

[5] Univ Pompeu Fabra, Dept Med & Life Sci, Barcelona 08003, Spain

来源：

NUTRIENTS | 2023年 / 15卷 / 18期

关键词：

adipose tissue; fructose; high-fat diet; leptin; non-esterified fatty acids; LIPOLYSIS;

D O I：

10.3390/nu15183909

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Non-alcoholic fatty liver disease is a sexual dimorphic disease, with adipose tissue playing an essential role. Our previous work showed that female rats fed a high-fat high-fructose diet devoid of cholesterol (HFHFr) developed simple hepatic steatosis dissociated from obesity. This study assessed the impact of the HFHFr diet on the male rat metabolism compared with data obtained for female rats. A total of 16 Sprague Dawley (SD) male rats were fed either a control (standard rodent chow and water) or HFHFr (high-fat diet devoid of cholesterol, plus 10% fructose in drinking water) diet for 3 months. Unlike female rats, and despite similar increases in energy consumption, HFHFr males showed increased adiposity and hyperleptinemia. The expression of hormone-sensitive lipase in the subcutaneous white adipose tissue was enhanced, leading to high free fatty acid and glycerol serum levels. HFHFr males presented hypertriglyceridemia, but not hepatic steatosis, partially due to enhanced liver PPAR alpha-related fatty acid beta-oxidation and the VLDL-promoting effect of leptin. In conclusion, the SD rats showed a sex-related dimorphic response to the HFHFr diet. Contrary to previous results for HFHFr female rats, the male rats were able to expand the adipose tissue, increase fatty acid catabolism, or export it as VLDL, avoiding liver lipid deposition.

引用

页数：15

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