The effects of glyphosate-based herbicide on the hypothalamic-pituitary thyroid axis are tissue-specific and dependent on age exposure

被引:4
作者
Oliveira, Jeane Maria [1 ]
Zenzeluk, Jamilli [1 ]
Bargi-Souza, Paula [2 ]
Szawka, Raphael Escorsim [2 ]
Romano, Marco Aurelio [1 ]
Romano, Renata Marino [1 ,3 ]
机构
[1] State Univ Cent West Unictr, Dept Med, Guarapuava, PR, Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Physiol & Biophys, Belo Horizonte, MG, Brazil
[3] Camargo Varela de Sa 03, BR-85040080 Guarapuava, PR, Brazil
关键词
Thyroid diseases; Gene expression; Thyroid metabolism; Endocrine-disrupting chemicals; Glyphosate-based herbicide; ENDOCRINE-DISRUPTING CHEMICALS; SUBCHRONIC EXPOSURE; MALE-RAT; EXPRESSION; MATURATION; TOXICITY; HORMONES; ALTERS; GUIDE; TSH;
D O I
10.1016/j.envpol.2023.122216
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The significant increase in glyphosate-based herbicide (GBH) use raises concerns about residues in the environment and food, potentially jeopardizing human health. The involvement of GBHs in the increased incidence of thyroid disorders is speculated, since glyphosate has been linked to an increased risk of thyroid disease in farmers. In this sense, this study aims to investigate the potential effects of low levels of GBH exposure (0, 0.5 or 5 mg/kg) from weaning (postnatal day PND23) to adult life (PND60 and PND90) in male Wistar rats on hypothalamic-pituitary-thyroid (HPT) axis function. The serum levels of T4 were increased. The hypothalamus showed reduced expression of Dio2, Thra1, and Thra2. The pituitary showed reduced expression of Mct8 and Dio2 and increased expression of Thra1. The thyroid showed increased expression of Tshr and Thra1. The heart showed increased expression of Mct8 and Myh6. The liver showed reduced expression of Mct8 and Thra2 and increased expression of Thra1. In thyroid morphometry, a decrease in both follicular diameter and area and decreased follicular and colloid diameters and areas were observed. These results suggested that GBH may affect several steps of HPT axis regulation at the transcriptional level in an age-dependent manner and alter the morphometric parameters of the thyroid gland and TH synthesis, with potential repercussions in the TH-target organs.
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页数:13
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共 71 条
[1]   Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka [J].
Abdul, K. S. M. ;
De Silva, P. Mangala C. S. ;
Ekanayake, E. M. D., V ;
Thakshila, W. A. K. G. ;
Gunarathna, S. D. ;
Gunasekara, T. D. K. S. C. ;
Jayasinghe, S. S. ;
Asanthi, H. B. ;
Chandana, E. P. S. ;
Chaminda, G. G. T. ;
Siribaddana, S. H. ;
Jayasundara, Nishad .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (06) :1-19
[2]  
[Anonymous], 2009, Emerging Contaminants-Nanomaterials, P1
[3]  
ATSDR, 2020, TOXICOLOGICAL PROFIL, P144
[4]   Novel aspects of T3 actions on GH and TSH synthesis and secretion: physiological implications [J].
Bargi-Souza, P. ;
Goulart-Silva, F. ;
Nunes, M. T. .
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2017, 59 (04) :R166-R177
[5]   Posttranscriptional actions of triiodothyronine on Tshb expression in TαT1 cells: New insights into molecular mechanisms of negative feedback [J].
Bargi-Souza, Paula ;
Goulart-Silva, Francemilson ;
Nunes, Maria Tereza .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2018, 478 :45-52
[6]   Triiodothyronine Rapidly Alters the TSH Content and the Secretory Granules Distribution in Male Rat Thyrotrophs by a Cytoskeleton Rearrangement-Independent Mechanism [J].
Bargi-Souza, Paula ;
Romano, Renata Marino ;
Salgado, Renato de Mayrinck ;
Goulart-Silva, Francemilson ;
Brunetto, Erika Lia ;
Tenorio Zorn, Telma Maria ;
Nunes, Maria Tereza .
ENDOCRINOLOGY, 2013, 154 (12) :4908-4918
[7]   Trends in glyphosate herbicide use in the United States and globally [J].
Benbrook, Charles M. .
ENVIRONMENTAL SCIENCES EUROPE, 2016, 28 :1-15
[8]   Occupational exposure to pesticides and thyroid function in Brazilian soybean farmers [J].
Bernieri, Tanandra ;
Rodrigues, Dabiana ;
Barbosa, Isadora Randon ;
Ardenghi, Patricia Grolli ;
da Silva, Luciano Basso .
CHEMOSPHERE, 2019, 218 :425-429
[9]   Paradigms of Dynamic Control of Thyroid Hormone Signaling [J].
Bianco, Antonio C. ;
Dumitrescu, Alexandra ;
Gereben, Balazs ;
Ribeiro, Miriam O. ;
Fonseca, Tatiana L. ;
Fernandes, Gustavo W. ;
Bocco, Barbara M. L. C. .
ENDOCRINE REVIEWS, 2019, 40 (04) :1000-1047
[10]   American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models [J].
Bianco, Antonio C. ;
Anderson, Grant ;
Forrest, Douglas ;
Galton, Valerie Anne ;
Gereben, Balazs ;
Kim, Brian W. ;
Kopp, Peter A. ;
Liao, Xiao Hui ;
Obregon, Maria Jesus ;
Peeters, Robin P. ;
Refetoff, Samuel ;
Sharlin, David S. ;
Simonides, Warner S. ;
Weiss, Roy E. ;
Williams, Graham R. .
THYROID, 2014, 24 (01) :88-168