Regio- and diastereoselective synthesis of new dispirocyclopentanebisoxindoles using a three-component strategy

被引：4
|
作者：
Moghaddam, F. Matloubi [1 ]
Aghamiri, Bagher [1 ]
Badpa, Sara [1 ]
机构：
[1] Sharif Univ Technol, Dept Chem, Lab Organ Synth & Nat Prod, Azadi St,POB, 111559516, Tehran, Iran
来源：
TETRAHEDRON | 2023年 / 141卷
关键词：
Dispirocyclopentanebisoxindoles; Isatin derivatives; Green conditions; SPIROOXINDOLE; CONSTRUCTION; POTENT; BISPIROOXINDOLES; CYCLOADDITION; SCAFFOLD; DESIGN;
D O I：
10.1016/j.tet.2023.133495
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and facile one-pot, multi-component reaction for the regio- and diastereoselective synthesis of novel dispirocyclopentanebisoxindoles has been reported by a reaction between phenyl-2(triphenylphosphoranylidene)ethanone and isatin derivatives. The great advantages of this synthetic protocol are the minimal reaction steps, short reaction time, and operational simplicity. In consequence, a variety of new dispirocyclopentanebisoxindole derivatives with potential medicinal applications were synthesized through one-pot and multi-component reaction in high to excellent yields.& COPY; 2023 Elsevier Ltd. All rights reserved.
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页数：10
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