Rh(III)-Catalyzed Double C-H Functionalization of Indoles with Cyclopropenones via Sequential C-H/C-C/C-H Bond Activation

被引：16

作者：

Zhang, Yan-Bo ^{[1
]}

Li, Bin-Shi ^{[1
]}

Xu, Guo-Jie ^{[1
]}

Sun, Wei ^{[1
]}

Sun, Meng ^{[1
]}

机构：

[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol, Minist Educ, Xian 710127, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 21期

基金：

中国国家自然科学基金;

关键词：

5+1 ANNULATION REACTION; HETEROCYCLES; STRATEGIES; CATALYSIS; ACCESS; ARENES;

D O I：

10.1021/acs.orglett.3c01292

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Anunprecedented Rh-(III)-catalyzed double C-H functionalizationof indoles with cyclopropenones via sequential C-H/C-C/C-Hbond activation has been developed. This procedure represents thefirst example for assembling of cyclopenta-[b]-indolesutilizing cyclopropenones as 3C synthons. This powerful approach showsexcellent chemo- and regioselectivity, wide functional group tolerance,and good reaction yields.

引用

页码：3922 / 3926

页数：5

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