Exploring the Remarkable Chemotherapeutic Potential of Polyphenolic Antioxidants in Battling Various Forms of Cancer

被引：24

作者：

Imran, Mohammad ^{[1
]}

Insaf, Areeba ^{[2
]}

Hasan, Nazeer ^{[3
]}

Sugandhi, Vrushabh V. ^{[4
]}

Shrestha, Deumaya ^{[5
]}

Paudel, Keshav Raj ^{[6
,7
]}

Jha, Saurav Kumar ^{[8
]}

Hansbro, Philip M. ^{[6
,7
]}

Dua, Kamal ^{[9
,10
]}

Devkota, Hari Prasad ^{[11
,12
]}

Mohammed, Yousuf ^{[1
,13
]}

机构：

[1] Univ Queensland, Frazer Inst, Fac Med, Therapeut Res Grp, Brisbane, Qld 4102, Australia

[2] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmacognosy & Phytochem, New Delhi 110062, India

[3] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India

[4] YB Chavan Coll Pharm, Dept Pharmaceut, Aurangabad 431001, India

[5] Mokpo Natl Univ, Dept Biosci, Muna 58554, South Korea

[6] Centenary Inst, Fac Sci, Ctr Inflammat, Sch Life Sci, Sydney, NSW 2007, Australia

[7] Univ Technol Sydney, Sydney, NSW 2007, Australia

[8] Mokpo Natl Univ, Dept Biomed Hlth & Life Convergence Sci, Muna 58554, South Korea

[9] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia

[10] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia

[11] Kumamoto Univ, Grad Sch Pharmaceut Sci, 5-1 Oe Honmachi, Kumamoto 8620973, Japan

[12] Gandaki Univ, Pharm Program, Pokhara 33700, Nepal

[13] Univ Queensland, Sch Pharm, Brisbane, Qld 4102, Australia

来源：

MOLECULES | 2023年 / 28卷 / 08期

基金：

英国医学研究理事会;

关键词：

flavonoids; antioxidant; anticancer; nanotechnology; combination therapy; GREEN TEA POLYPHENOL; ANTICANCER ACTIVITY; PROSTATE-CANCER; GROWTH-INHIBITION; CELL-DEATH; IN-VITRO; (-)-EPIGALLOCATECHIN GALLATE; TRANSDERMAL DELIVERY; GENE-EXPRESSION; ELLAGIC ACID;

D O I：

10.3390/molecules28083475

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plant-derived compounds, specifically antioxidants, have played an important role in scavenging the free radicals present under diseased conditions. The persistent generation of free radicals in the body leads to inflammation and can result in even more severe diseases such as cancer. Notably, the antioxidant potential of various plant-derived compounds prevents and deregulates the formation of radicals by initiating their decomposition. There is a vast literature demonstrating antioxidant compounds' anti-inflammatory, anti-diabetic, and anti-cancer potential. This review describes the molecular mechanism of various flavonoids, such as quercetin, kaempferol, naringenin, epicatechin, and epicatechin gallate, against different cancers. Additionally, the pharmaceutical application of these flavonoids against different cancers using nanotechnologies such as polymeric, lipid-based nanoparticles (solid-lipid and liquid-lipid), liposomes, and metallic nanocarriers is addressed. Finally, combination therapies in which these flavonoids are employed along with other anti-cancer agents are described, indicating the effective therapies for the management of various malignancies.

引用

页数：20

共 1 条

[1] Exploring the therapeutic potential of edible vegetables, fruits, and spices against cancer in various cell lines
Ali, Md. Rahmat
Reza, A. S. M. Ali
Haque, Md. Anwarul
Islam, Md. Jannatul
Hossain, Md. Rezwan
Mollah, Md. Ibrahim
Islam, Md. Badrul
Sarker, Joy
Rashid, Mamunur
Sadik, Md. Golam
Cicia, Donatella
Capasso, Raffaele
Kazi, Mohsin
Alam, A. H. M. Khurshid
JOURNAL OF CANCER, 2024, 15 (03): : 577 - 589

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