Role of in vivo confocal microscopy in dry eye disease and eye pain

被引：10

作者：

Shetty, Rohit ^{[1
]}

Dua, Harminder S. ^{[2
]}

Tong, Louis ^{[3
]}

Kundu, Gairik ^{[1
]}

Khamar, Pooja ^{[1
]}

Gorimanipalli, Bhavya ^{[1
]}

D'Souza, Sharon ^{[1
,4
]}

机构：

[1] Narayana Nethralaya Eye Hosp, Dept Cornea & Refract Surg, Bangalore, Karnataka, India

[2] Univ Nottingham, Queens Med Ctr, Dept Ophthalmol & Visual Sci, Nottingham, England

[3] Duke Natl Univ Singapore, Singapore Eye Res Inst, Singapore Natl Eye Ctr, Eye Acad Clin Program,Cornea & External Eye Dis Se, Singapore, Singapore

[4] Narayana Nethralaya Eye Hosp, Dept Cornea & Refract Surg, Bengaluru 560010, Karnataka, India

来源：

INDIAN JOURNAL OF OPHTHALMOLOGY | 2023年 / 71卷 / 04期

关键词：

Cornea; eye pain; IVCM; normal and dry eye; CORNEAL THICKNESS MEASUREMENT; NERVE PLEXUS; DENSITY; ENDOTHELIUM; INNERVATION; EPITHELIUM; MORPHOLOGY; DIAGNOSIS; FEATURES;

D O I：

10.4103/IJO.IJO_3013_22

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Dry eye disease is known to have a lot of variability in presentation with overlapping subtypes. Understanding the pathology of this condition will guide therapeutic options. In vivo confocal microscopy is a diagnostic and imaging modality that provides high magnification and high-resolution images of all layers of the cornea and ocular surface. Various structures in the cornea and their alterations due to dry eye have been imaged. The impact of the tear film instability, inflammation, and altered homeostasis on the corneal epithelium, nerves, keratocytes, and dendritic cells have been evaluated across different studies. In addition, key features of IVCM in patients with neuropathic pain have been highlighted in this paper.

引用

页码：1099 / 1104

页数：6

共 45 条

[1]

Aggarwal S, 2015, OCUL SURF, V13, P250, DOI 10.1016/j.jtos.2015.01.005

[2] Corneal nerves in health and disease [J].

Al-Aqaba, Mouhamed A. ;

Dhillon, Virinder K. ;

Mohammed, Imran ;

Said, Dalia G. ;

Dua, Harminder S. .

PROGRESS IN RETINAL AND EYE RESEARCH, 2019, 73

[3] In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles [J].

Al-Aqaba, Mouhamed Ali ;

Anis, Fady S. ;

Mohammed, Imran ;

Yapa, Anjali Dias Samarawickrama ;

Amoaku, Winfried M. ;

Dua, Harminder Singh Singh .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2021, 105 (02) :285-289

[4] Neural basis of sensation in intact and injured corneas [J].

Belmonte, C ;

Acosta, MC ;

Gallar, J .

EXPERIMENTAL EYE RESEARCH, 2004, 78 (03) :513-525

[5] Relation between corneal innervation with confocal microscopy and corneal sensitivity with noncontact esthesiometry in patients with dry eye [J].

Benitez-del-Castillo, Jose M. ;

Acosta, M. Carmen ;

Wassfi, Mohamed A. ;

Diaz-Valle, David ;

Gegundez, Jose A. ;

Fernandez, Cristina ;

Garcia-Sanchez, Julian .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2007, 48 (01) :173-181

[6] Confocal microscopy of the cornea [J].

Böhnke, M ;

Masters, BR .

PROGRESS IN RETINAL AND EYE RESEARCH, 1999, 18 (05) :553-628

[7] Decreased density of corneal basal epithelium and subbasal corneal nerve bundle changes in patients with diabetic retinopathy [J].

Chang, Pei-Yao ;

Carrel, Hyman ;

Huang, Jen-Shang ;

Wang, I-Jong ;

Hou, Yu-Chih ;

Chen, Wei-Li ;

Wang, Jiun-Yi ;

Hu, Fung-Rong .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2006, 142 (03) :488-490

[8] In Vivo Confocal Microscopy of Corneal Nerves: Analysis and Clinical Correlation [J].

Cruzat, Andrea ;

Pavan-Langston, Deborah ;

Hamrah, Pedram .

SEMINARS IN OPHTHALMOLOGY, 2010, 25 (5-6) :171-177

[9] Corneal Confocal Microscopy Features and Tear Molecular Profile in Study Participants with Discordance between Ocular Surface Disease Clinical Signs and Discomfort [J].

D'Souza, Sharon ;

Shetty, Rohit ;

Nair, Archana Padmanabhan ;

Agrawal, Ruchika ;

Dickman, Mor M. ;

Khamar, Pooja ;

Nuijts, Rudy M. M. A. ;

Ghosh, Arkasubhra ;

Sethu, Swaminathan .

JOURNAL OF CLINICAL MEDICINE, 2022, 11 (09)

[10] An in vivo confocal masked study on corneal epithelium and subbasal nerves in patients with dry eye [J].

del Castillo, JMB ;

Wasfy, MAS ;

Fernandez, C ;

Garcia-Sanchez, J .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (09) :3030-3035

← 1 2 3 4 5 →