Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment

被引：57

作者：

Ruan, Ruiwen ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Li, Xuan ^{[1
,2
]}

Huang, Chunye ^{[1
,2
]}

Zhang, Zhanmin ^{[1
,2
]}

Zhong, Hongguang ^{[1
,2
]}

Zeng, Shaocheng ^{[1
,2
]}

Shi, Qianqian ^{[1
,2
]}

Xia, Yang ^{[1
,2
]}

Zeng, Qinru ^{[1
,2
]}

Wen, Qin ^{[1
,2
]}

Chen, Jingyi ^{[1
,2
]}

Dai, Xiaofeng ^{[1
,2
]}

Xiong, Jianping ^{[1
,2
]}

Xiang, Xiaojun ^{[1
,2
]}

Lei, Wan ^{[1
,2
]}

Deng, Jun ^{[1
,2
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 1, Dept Oncol, Nanchang 330006, Jiangxi, Peoples R China

[2] Jiangxi Key Lab lndividualized Canc Therapy, 17 Yongwai St, Nanchang 330006, Jiangxi, Peoples R China

来源：

MOLECULAR CANCER | 2023年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Fibroblast growth factor receptor; Immune checkpoint blockade; Tumor microenvironment; Immunotherapy; GROWTH-FACTOR RECEPTOR; TO-MESENCHYMAL TRANSITION; METASTATIC UROTHELIAL CARCINOMA; IMMUNOGENIC CELL-DEATH; MHC CLASS-I; SUPPRESSOR-CELLS; BREAST-CANCER; ANTITUMOR IMMUNITY; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1186/s12943-023-01761-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

BackgroundFibroblast growth factors (FGFs) and their receptors (FGFRs) play a crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving tumorigenesis. Therefore, many studies have targeted FGF/FGFR signaling for cancer therapy and several FGFR inhibitors have promising results in different tumors but treatment efficiency may still be improved. The clinical use of immune checkpoint blockade (ICB) has resulted in sustained remission for patients.MainAlthough there is limited data linking FGFR inhibitors and immunotherapy, preclinical research suggest that FGF/FGFR signaling is involved in regulating the tumor microenvironment (TME) including immune cells, vasculogenesis, and epithelial-mesenchymal transition (EMT). This raises the possibility that ICB in combination with FGFR-tyrosine kinase inhibitors (FGFR-TKIs) may be feasible for treatment option for patients with dysregulated FGF/FGFR signaling.ConclusionHere, we review the role of FGF/FGFR signaling in TME regulation and the potential mechanisms of FGFR-TKI in combination with ICB. In addition, we review clinical data surrounding ICB alone or in combination with FGFR-TKI for the treatment of FGFR-dysregulated tumors, highlighting that FGFR inhibitors may sensitize the response to ICB by impacting various stages of the "cancer-immune cycle".

引用

页数：22

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