Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment

被引：57

作者：

Ruan, Ruiwen ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Li, Xuan ^{[1
,2
]}

Huang, Chunye ^{[1
,2
]}

Zhang, Zhanmin ^{[1
,2
]}

Zhong, Hongguang ^{[1
,2
]}

Zeng, Shaocheng ^{[1
,2
]}

Shi, Qianqian ^{[1
,2
]}

Xia, Yang ^{[1
,2
]}

Zeng, Qinru ^{[1
,2
]}

Wen, Qin ^{[1
,2
]}

Chen, Jingyi ^{[1
,2
]}

Dai, Xiaofeng ^{[1
,2
]}

Xiong, Jianping ^{[1
,2
]}

Xiang, Xiaojun ^{[1
,2
]}

Lei, Wan ^{[1
,2
]}

Deng, Jun ^{[1
,2
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 1, Dept Oncol, Nanchang 330006, Jiangxi, Peoples R China

[2] Jiangxi Key Lab lndividualized Canc Therapy, 17 Yongwai St, Nanchang 330006, Jiangxi, Peoples R China

来源：

MOLECULAR CANCER | 2023年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Fibroblast growth factor receptor; Immune checkpoint blockade; Tumor microenvironment; Immunotherapy; GROWTH-FACTOR RECEPTOR; TO-MESENCHYMAL TRANSITION; METASTATIC UROTHELIAL CARCINOMA; IMMUNOGENIC CELL-DEATH; MHC CLASS-I; SUPPRESSOR-CELLS; BREAST-CANCER; ANTITUMOR IMMUNITY; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1186/s12943-023-01761-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

BackgroundFibroblast growth factors (FGFs) and their receptors (FGFRs) play a crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving tumorigenesis. Therefore, many studies have targeted FGF/FGFR signaling for cancer therapy and several FGFR inhibitors have promising results in different tumors but treatment efficiency may still be improved. The clinical use of immune checkpoint blockade (ICB) has resulted in sustained remission for patients.MainAlthough there is limited data linking FGFR inhibitors and immunotherapy, preclinical research suggest that FGF/FGFR signaling is involved in regulating the tumor microenvironment (TME) including immune cells, vasculogenesis, and epithelial-mesenchymal transition (EMT). This raises the possibility that ICB in combination with FGFR-tyrosine kinase inhibitors (FGFR-TKIs) may be feasible for treatment option for patients with dysregulated FGF/FGFR signaling.ConclusionHere, we review the role of FGF/FGFR signaling in TME regulation and the potential mechanisms of FGFR-TKI in combination with ICB. In addition, we review clinical data surrounding ICB alone or in combination with FGFR-TKI for the treatment of FGFR-dysregulated tumors, highlighting that FGFR inhibitors may sensitize the response to ICB by impacting various stages of the "cancer-immune cycle".

引用

页数：22

共 50 条

[31] The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment [J].

Poon, Edmund ;

Mullins, Stefanie ;

Watkins, Amanda ;

Williams, Geoffrey S. ;

Koopmann, Jens-Oliver ;

Di Genova, Gianfranco ;

Cumberbatch, Marie ;

Veldman-Jones, Margaret ;

Grosskurth, Shaun E. ;

Sah, Vasu ;

Schuller, Alwin ;

Reimer, Corrine ;

Dovedi, Simon J. ;

Smith, Paul D. ;

Stewart, Ross ;

Wilkinson, Robert W. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5

[32] Conserved angio-immune subtypes of the tumor microenvironment predict response to immune checkpoint blockade therapy [J].

Subramanian, Madhav ;

Ul Kabir, Ashraf ;

Barisas, Derek ;

Krchma, Karen ;

Choi, Kyunghee .

CELL REPORTS MEDICINE, 2023, 4 (01)

[33] Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response [J].

Ahmed, Kazi Mokim ;

Veeramachaneni, Ratna ;

Deng, Defeng ;

Putluri, Nagireddy ;

Putluri, Vasanta ;

Cardenas, Maria F. ;

Wheeler, David A. ;

Decker, William K. ;

Frederick, Andy, I ;

Kazi, Sawad ;

Sikora, Andrew G. ;

Sandulache, Vlad C. ;

Frederick, Mitchell J. .

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[34] NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells [J].

Takase, Nobuhisa ;

Koma, Yu-ichiro ;

Urakawa, Naoki ;

Nishio, Mari ;

Arai, Noriaki ;

Akiyama, Hiroaki ;

Shigeoka, Manabu ;

Kakeji, Yoshihiro ;

Yokozaki, Hiroshi .

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[35] Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging concepts [J].

Naushad Ahmad Khan ;

Mohammad Asim ;

Kabir H. Biswas ;

Amani N Alansari ;

Harman Saman ;

Mohammad Zahid Sarwar ;

Kudaibergen Osmonaliev ;

Shahab Uddin .

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[36] Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non-small cell cancer [J].

Mao, Wenjun ;

Cai, Yun ;

Chen, Danrong ;

Jiang, Guanyu ;

Xu, Yongrui ;

Chen, Ruo ;

Wang, Fengxu ;

Wang, Xuehai ;

Zheng, Mingfeng ;

Zhao, Xinyuan ;

Mei, Jie .

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[37] Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy [J].

Xiao, Yuling ;

Chen, Jiang ;

Zhou, Hui ;

Zeng, Xiaodong ;

Ruan, Zhiping ;

Pu, Zhangya ;

Jiang, Xingya ;

Matsui, Aya ;

Zhu, Lingling ;

Amoozgar, Zohreh ;

Chen, Dean Shuailin ;

Han, Xiangfei ;

Duda, Dan G. ;

Shi, Jinjun .

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[38] C5aR1 blockade reshapes immunosuppressive tumor microenvironment and synergizes with immune checkpoint blockade therapy in high-grade serous ovarian cancer [J].

Zhang, Chen ;

Cao, Kankan ;

Yang, Moran ;

Wang, Yiying ;

He, Mengdi ;

Lu, Jiaqi ;

Huang, Yan ;

Zhang, Guodong ;

Liu, Haiou .

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[39] Identification of a novel extracellular inhibitor of FGF2/FGFR signaling axis by combined virtual screening and NMR spectroscopy approach [J].

Pagano, Katiuscia ;

Listro, Roberta ;

Linciano, Pasquale ;

Rossi, Daniela ;

Longhi, Elisa ;

Taraboletti, Giulia ;

Molinari, Henriette ;

Collina, Simona ;

Ragona, Laura .

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[40] Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity [J].

Abe, Shinya ;

Nagata, Hiroshi ;

Crosby, Erika J. ;

Inoue, Yoshiyuki ;

Kaneko, Kensuke ;

Liu, Cong-Xiao ;

Yang, Xiao ;

Wang, Tao ;

Acharya, Chaitanya R. ;

Agarwal, Pankaj ;

Snyder, Joshua ;

Gwin, William ;

Morse, Michael A. ;

Zhong, Pei ;

Lyerly, Herbert Kim ;

Osada, Takuya .

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