Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions

被引：11

作者：

Fan, Liangxin ^{[1
]}

Zhu, Xinxin ^{[1
]}

Liu, Xingyuan ^{[1
]}

He, Fangyu ^{[1
]}

Yang, Guoyu ^{[1
]}

Xu, Cuilian ^{[1
]}

Yang, Xifa ^{[2
]}

机构：

[1] Henan Agr Univ, Sch Sci, Dept Chem Biol, Zhengzhou 450002, Peoples R China

[2] Henan Agr Univ, Inst Pesticide, Sch Plant Protect, Zhengzhou 450002, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 04期

基金：

中国国家自然科学基金;

关键词：

palladium; tricyclic indoles; domino reaction; catalyst; total synthesis; GP120-CD4; BINDING; ERGOT ALKALOIDS; STRUCTURE ELUCIDATION; (+)-LYSERGIC ACID; CHLOROPEPTIN-I; CASCADE; CYCLIZATION; INHIBITORS; ARYLATION; WELWITINDOLINONES;

D O I：

10.3390/molecules28041647

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3,n-fused (n = 4-7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformations have received much attention in recent years. This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products.

引用

页数：24

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