Hedyocoronins A and B: two new oleanane saponins from the aerial parts of Hedyotis coronaria

被引：2
|
作者：
Nguyen-Kim-Tuyen Pham [1 ]
Hoang-Minh Thai [2 ]
Thi-Anh-Tuyet Nguyen [3 ]
Thi-Nga Vo [4 ]
Kim-Phi-Phung Nguyen [5 ]
Thi-Hoai-Thu Nguyen [6 ]
机构：
[1] Sai Gon Univ, Fac Environm Sci, Ho Chi Minh City, Vietnam
[2] Tam Phu High Sch, Dept Chem, Ho Chi Minh City, Vietnam
[3] Ho Chi Minh City Univ Educ, Dept Chem, Ho Chi Minh City, Vietnam
[4] Ho Chi Minh City Univ Technol & Educ, Dept Chem Technol, Ho Chi Minh City, Vietnam
[5] Vietnam Natl Univ Ho Chi Minh City, Univ Sci, Fac Chem, Ho Chi Minh City, Vietnam
[6] Univ Med & Pharm Ho Chi Minh City, Fac Basic Sci, Ho Chi Minh City, Vietnam
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 08期
关键词：
Hedyotis coronaria; hedyocoronin A; hedyocoronin B; oleanane saponin; cytotoxicity; GLYCOSIDES; MIGRATION;
D O I：
10.1080/14786419.2021.2003357
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new oleanane saponins, hedyocoronin A (1) and hedyocoronin B (2), were isolated from the aerial parts of Hedyotis coronaria (Kurz) Craib, Rubiaceae, collected at Da Oai district, Lam Dong province in Vietnam. Their chemical structures were elucidated by HR-MS, 1D and 2D-NMR spectra, along with the comparison with those reported in the literature. Compounds 1 and 2 showed weak cytotoxicity against KB and HeLa-S3 cancer cell lines with IC50 values of more than 54 mu M.
引用
收藏
页码：1292 / 1299
页数：8
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