A Review on Latent Autoimmune Diabetes in Adults

被引：5
作者：
Ravikumar, Vijay [1 ]
Ahmed, Ariba [1 ]
Anjankar, Ashish [2 ]
机构：
[1] Datta Meghe Inst Higher Educ & Res, Jawaharlal Nehru Med Coll, Med Educ, Wardha, India
[2] Datta Meghe Inst Higher Educ & Res, Jawaharlal Nehru Med Coll, Biochem, Wardha, India
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 10期
关键词：
type 1 and type 2 diabetes mellitus; dpp-4; inhibitors; metformin; intensive insulin therapy; latent autoimmune diabetes in adults (lada); BETA-CELL FUNCTION; CHRONIC COMPLICATIONS; EARLY INSULIN; TYPE-1; LADA; AUTOANTIBODIES; MULTICENTER; PHENOTYPE; DIAGNOSIS; AGE;
D O I：
10.7759/cureus.47915
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Latent autoimmune diabetes (LADA) is an unique form of diabetes that has characteristics of both type 1 and type 2 diabetes. Type 1.5 diabetes also known as LADA is occasionally confused for type 2 diabetes because there is delay in presenting features and early insulin independence. LADA, on the other hand, is an autoimmune disorder that differs from type 2 diabetes in that autoantibodies against pancreatic beta cells are what characterise it. Insulin production eventually diminishes due to the autoimmune destruction of pancreatic beta cells as a result of the pathophysiology of LADA. Autoantibodies to glutamic acid decarboxylase (GAD), islet antigen-2 (IA-2), and insulin are frequently detected in LADA patients. These autoantibodies have important implications for therapy strategies and are essential in differentiating LADA from type 2 diabetes. LADA clinical management is very challenging. The aim of this article is to view the characteristics, disease presentation, diagnostic challenges, progression and treatment modalities of LADA.
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页数：8
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