Auxin transport at the endoplasmic reticulum: roles and structural similarity of PIN-FORMED and PIN-LIKES

被引：7
作者：
Ung, Kien Lam [1 ]
Schulz, Lukas [2 ]
Kleine-Vehn, Juergen [3 ,4 ]
Pedersen, Bjorn Panyella [1 ]
Hammes, Ulrich Z. [2 ]
机构：
[1] Aarhus Univ, Dept Mol Biol & Genet, DK-8000 Aarhus, Denmark
[2] Tech Univ Munich, Sch Life Sci Weihenstephan, Plant Syst Biol, D-85354 Freising Weihenstephan, Germany
[3] Univ Freiburg, Inst Biol 2, Dept Mol Plant Physiol MoPP, D-79104 Freiburg, Germany
[4] Univ Freiburg, Ctr Integrat Biol Signalling Studies CIBSS, D-79104 Freiburg, Germany
来源：
JOURNAL OF EXPERIMENTAL BOTANY | 2023年 / 74卷 / 22期
基金：
欧盟地平线“2020”; 奥地利科学基金会; 欧洲研究理事会;
关键词：
Auxin; crossover elevator mechanism; endoplasmic reticulum; PIN-LIKES; PIN-FORMED; proton motive force; topology; uniport; PLASMA-MEMBRANE; LATERAL ROOT; CRYSTAL-STRUCTURE; ARABIDOPSIS; MECHANISM; PROTEINS; PH; LOCALIZATION; HOMEOSTASIS; GRAVITROPISM;
D O I：
10.1093/jxb/erad192
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Auxin is a crucial plant hormone that controls a multitude of developmental processes. The directional movement of auxin between cells is largely facilitated by canonical PIN-FORMED proteins in the plasma membrane. In contrast, non-canonical PIN-FORMED proteins and PIN-LIKES proteins appear to reside mainly in the endoplasmic reticulum. Despite recent progress in identifying the roles of the endoplasmic reticulum in cellular auxin responses, the transport dynamics of auxin at the endoplasmic reticulum are not well understood. PIN-LIKES are structurally related to PIN-FORMED proteins, and recently published structures of these transporters have provided new insights into PIN-FORMED proteins and PIN-LIKES function. In this review, we summarize current knowledge on PIN-FORMED proteins and PIN-LIKES in intracellular auxin transport. We discuss the physiological properties of the endoplasmic reticulum and the consequences for transport processes across the ER membrane. Finally, we highlight the emerging role of the endoplasmic reticulum in the dynamics of cellular auxin signalling and its impact on plant development. This review discusses auxin transport across the endoplasmic reticulum membrane by non-canonical PIN-FORMED (PIN) proteins and the related PIN-LIKES (PILS) proteins in the light of recent findings on the PIN structure.
引用
收藏
页码：6893 / 6903
页数：11
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