Impact of pelvic radiation therapy in patients with early neuroendocrine cervical carcinoma and no residual disease in the radical hysterectomy specimen: a NeCTuR study

被引:0
作者
Khurana, Nilsha [2 ]
Frumovitz, Michael [3 ]
Legarreta, Alejandra Flores [2 ]
Ramalingam, Preetha [4 ]
Jhingran, Anuja [5 ]
Bhosale, Priya [6 ]
Saab, Reem [3 ]
Gonzales, Naomi R. R. [3 ]
Chisholm, Gary B. [3 ]
Salvo, Gloria [1 ,3 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Gynecol Oncol & Reprod Med, Houston, TX 77030 USA
[2] Touro Univ, Neurol, New York, NY USA
[3] Univ Texas MD Anderson Canc Ctr, Gynecol Oncol & Reprod Med, Houston, TX USA
[4] Univ Texas MD Anderson Canc Ctr, Pathol, Houston, TX USA
[5] Univ Texas MD Anderson Canc Ctr, Radiat Oncol, Houston, TX USA
[6] Univ Texas MD Anderson Canc Ctr, Dept Abdominal Imaging, Houston, TX USA
关键词
Cervical Cancer; Radiotherapy; Neuroendocrine Tumors; SMALL-CELL CARCINOMA; PROGNOSTIC-FACTORS; RANDOMIZED-TRIAL; STAGE; SURGERY; CANCER; TUMORS;
D O I
10.1136/ijgc-2023-005053
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
ObjectiveThe impact of adjuvant pelvic radiation therapy on the rate and location of recurrences was evaluated in patients with early-stage (IA1-IB2) neuroendocrine cervical carcinoma who underwent prior conization or polypectomy with no residual disease and negative nodes in the subsequent upfront radical hysterectomy specimen. As a secondary objective, disease-free and overall survival were analyzed.MethodsWe searched the Neuroendocrine Cervical Tumor Registry (NeCTuR) to identify patients with clinical early-stage neuroendocrine cervical carcinoma with no residual disease in the specimen from upfront radical surgery and negative nodes. Patients who received pelvic radiation therapy were compared with those who did not, regardless of whether they received adjuvant chemotherapy.ResultsTwenty-seven patients met the inclusion criteria, representing 17% of all patients with clinical early-stage disease who underwent upfront radical hysterectomy included in the NeCTuR registry. The median age was 36.0 years (range 26.0-51.0). Six (22%) patients had stage IA, 20 (74%) had stage IB1, and one (4%) had stage IB2 disease. Seven (26%) patients received adjuvant radiation therapy and 20 (74%) did not. All seven patients in the radiation group and 14 (70%) in the no-radiation group received adjuvant chemotherapy (p=0.16). Fifteen percent (4/27) of patients had a recurrence, 14% (1/7) in the radiation group and 15% (3/20) in the no-radiation group (p=0.99). In the radiation group the recurrence was outside the pelvis, and in the no-radiation group, 67% (2/3) recurred outside the pelvis and 33% (1/3) recurred both inside and outside the pelvis (p=0.99). In the radiation group the 5-year disease-free and overall survival rates were 100% while, in the no-radiation group, the 5-year disease-free and overall survival rates were 81% (95% CI 61% to 100%) (p=0.99) and 80% (95% CI 58% to 100%) (p=0.95), respectively.ConclusionsFor patients with no residual disease and negative nodes in the upfront radical hysterectomy specimen, our study did not find that pelvic radiation therapy improves survival.
引用
收藏
页码:209 / 215
页数:7
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