Activity of Nonnucleoside Inhibitors of O6-methylguanine-DNA Methyltransferase Repair Enzyme in Human Cells In Vitro

被引：1
|
作者：
Zhuvaka, K. S. [1 ]
Volynets, G. P. [1 ]
Ruban, T. P. [1 ]
Nidoeva, Z. M. [1 ]
Iatsyshyna, A. P. [1 ]
Macewizc, L. L. [1 ]
Bdzhola, V. G. [1 ]
Yarmoluk, S. M. [1 ]
Lukash, L. L. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Inst Mol Biol & Genet, Dept Human Genet, UA-03680 Kiev, Ukraine
来源：
CYTOLOGY AND GENETICS | 2023年 / 57卷 / 06期
关键词：
Repair enzyme MGMT; new potential MGMT inhibitors; alkylating agent; cell line HEp-2; O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE; DNA-REPAIR; O-6-BENZYLGUANINE; INACTIVATION; TEMOZOLOMIDE; DERIVATIVES; MGMT; POTENTIATION; CYTOTOXICITY; RESISTANCE;
D O I：
10.3103/S0095452723060105
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The inhibition of MGMT leads to increasing effectiveness of alkylating chemotherapy. In this study, new potential MGMT inhibitors were tested. It was found that some compounds demonstrate low cytotoxicity and high effectiveness in human cells in vitro.
引用
收藏
页码：556 / 566
页数：11
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