Local Field Potentials Predict Motor Performance in Deep Brain Stimulation for Parkinson's Disease

被引：12

作者：

Busch, Johannes L. ^{[1
,2
]}

Kaplan, Jonathan ^{[1
]}

Bahners, Bahne H. ^{[3
]}

Roediger, Jan ^{[1
]}

Faust, Katharina ^{[4
]}

Schneider, Gerd-Helge ^{[4
]}

Florin, Esther ^{[3
]}

Schnitzler, Alfons ^{[3
]}

Krause, Patricia ^{[1
]}

Kuehn, Andrea A. ^{[1
,5
,6
]}

机构：

[1] Charite Univ Med Berlin, Dept Neurol, Movement Disorders & Neuromodulat Unit, Charitepl 1, D-10117 Berlin, Germany

[2] Charite Univ Med Berlin, Berlin Inst Hlth, BIH Biomed Innovat Acad, BIH Charite Jr Clinician Scientist Program, Berlin, Germany

[3] Heinrich Heine Univ, Inst Clin Neurosci & Med Psychol, Med Fac, Dusseldorf, Germany

[4] Charite Univ Med Berlin, Dept Neurosurg, Berlin, Germany

[5] Charite Univ Med Berlin, NeuroCure, Berlin, Germany

[6] Deutsch Zentrum Neurodegenerat Erkrankungen DZNE, Berlin, Germany

来源：

MOVEMENT DISORDERS | 2023年 / 38卷 / 12期

关键词：

deep brain stimulation; Parkinson's disease; local field potentials; PARKINSONS-DISEASE; OSCILLATIONS; IMPROVEMENT;

D O I：

10.1002/mds.29626

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Deep brain stimulation (DBS) is an effective treatment option for patients with Parkinson's disease (PD). However, clinical programming remains challenging with segmented electrodes.Objective Using novel sensing-enabled neurostimulators, we investigated local field potentials (LFPs) and their modulation by DBS to assess whether electrophysiological biomarkers may facilitate clinical programming in chronically implanted patients.Methods Sixteen patients (31 hemispheres) with PD implanted with segmented electrodes in the subthalamic nucleus and a sensing-enabled neurostimulator were included in this study. Recordings were conducted 3 months after DBS surgery following overnight withdrawal of dopaminergic medication. LFPs were acquired while stimulation was turned OFF and during a monopolar review of both directional and ring contacts. Directional beta power and stimulation-induced beta power suppression were computed. Motor performance, as assessed by a pronation-supination task, clinical programming and electrode placement were correlated to directional beta power and stimulation-induced beta power suppression.Results Better motor performance was associated with stronger beta power suppression at higher stimulation amplitudes. Across directional contacts, differences in directional beta power and the extent of stimulation-induced beta power suppression predicted motor performance. However, within individual hemispheres, beta power suppression was superior to directional beta power in selecting the contact with the best motor performance. Contacts clinically activated for chronic stimulation were associated with stronger beta power suppression than non-activated contacts.Conclusions Our results suggest that stimulation-induced beta power suppression is superior to directional beta power in selecting the clinically most effective contact. In sum, electrophysiological biomarkers may guide programming of directional DBS systems in PD patients.

引用

页码：2185 / 2196

页数：12

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