When Alzheimer's is LATE: Why Does it Matter?

被引：23
|
作者：
Nelson, Peter T. [1 ,2 ,3 ]
Schneider, Julie A. [4 ,5 ]
Jicha, Gregory A. [3 ,6 ]
Duong, Michael Tran [7 ]
Wolk, David A. [7 ]
机构：
[1] Univ Kentucky, Alzheimers Dis Res Ctr, 575 Lee Todd Bldg,789 S Limestone, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Pathol, Lexington, KY USA
[3] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY USA
[4] Rush Univ, Dept Pathol, Med Coll, Chicago, IL USA
[5] Rush Univ, Med Coll, Dept Neurol Sci, Chicago, IL USA
[6] Univ Kentucky, Dept Neurol, Lexington, KY USA
[7] Univ Penn, Dept Neurol, Philadelphia, PA USA
来源：
ANNALS OF NEUROLOGY | 2023年 / 94卷 / 02期
关键词：
HIPPOCAMPAL SCLEROSIS; TDP-43; IMMUNOREACTIVITY; DISEASE; PATHOLOGY; BRAIN; ENCEPHALOPATHY; ASSOCIATION; IMPAIRMENT; ATROPHY; AD;
D O I：
10.1002/ana.26711
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recent therapeutic advances provide heightened motivation for accurate diagnosis of the underlying biologic causes of dementia. This review focuses on the importance of clinical recognition of limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE affects approximately one-quarter of older adults and produces an amnestic syndrome that is commonly mistaken for Alzheimer's disease (AD). Although AD and LATE often co-occur in the same patients, these diseases differ in the protein aggregates driving neuropathology (A beta amyloid/tau vs TDP-43). This review discusses signs and symptoms, relevant diagnostic testing, and potential treatment implications for LATE that may be helpful for physicians, patients, and families. ANN NEUROL 2023
引用
收藏
页码：211 / 222
页数：12
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