Bioinspired and Inflammation-Modulatory Glycopeptide Hydrogels for Radiation-Induced Chronic Skin Injury Repair

被引：36

作者：

Feng, Zujian ^{[1
]}

Zhang, Yumin ^{[2
,3
]}

Yang, Chunfang ^{[1
]}

Liu, Xiang ^{[4
]}

Huangfu, Yini ^{[4
]}

Zhang, Chuangnian ^{[1
]}

Huang, Pingsheng ^{[1
]}

Dong, Anjie ^{[4
]}

Liu, Jinjian ^{[2
,3
]}

Liu, Jianfeng ^{[2
,3
]}

Kong, Deling ^{[5
]}

Wang, Weiwei ^{[1
,6
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Biomed Engn, Tianjin Key Lab Biomat Res, Tianjin 300192, Peoples R China

[2] Chinese Acad Med Sci, Key Lab Radiopharmacokinet Innovat Drugs, Tianjin 300192, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Radiat Med, Tianjin 300192, Peoples R China

[4] Tianjin Univ, Sch Chem Engn & Technol, Dept Polymer Sci & Engn, Key Lab Syst Bioengn,Minist Educ, Tianjin 300072, Peoples R China

[5] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China

[6] Chinese Acad Med Sci, Key Lab Innovat Cardiovasc Devices, Beijing 100144, Peoples R China

来源：

ADVANCED HEALTHCARE MATERIALS | 2023年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

chronic wound healing; glycopeptide hydrogels; immunomodulation; macrophages polarization; radiation-induced skin injury; ROS scavenging; MECHANISMS; MACROPHAGES; AMIFOSTINE; EXPOSURE; PROMOTES; MATRIX;

D O I：

10.1002/adhm.202201671

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Clinical wound management of radiation-induced skin injury (RSI) remains a great challenge due to acute injuries induced by excessive reactive oxygen species (ROS), and the concomitant repetitive inflammatory microenvironment caused by an imbalance in macrophage homeostasis. Herein, a cutaneous extracellular matrix (ECM)-inspired glycopeptide hydrogel (GK@TA(gel)) is rationally designed for accelerating wound healing through modulating the chronic inflammation in RSI. The glycopeptide hydrogel not only replicates ECM-like glycoprotein components and nanofibrous architecture, but also displays effective ROS scavenging and radioprotective capability that can reduce the acute injuries after exposure to irradiation. Importantly, the mannose receptor (MR) in GK@TA(gel) exhibits high affinity and bioactivity to drive the M2 macrophage polarization, thereby overcoming the persistent inflammatory microenvironment in chronic RSI. The repair of RSI in mice demonstrates that GK@TA(gel) significantly reduces the hyperplasia of epithelial, promotes appendage regeneration and angiogenesis, and decreased the proinflammatory cytokine expression, which is superior to the treatment of commercial radioprotective drug amifostine. Collectively, the ECM-mimetic hydrogel dressing can protect the tissue from irradiation and heal the chronic wound in RSI, holding great potential in clinical wound management and tissue regeneration.

引用

页数：14

共 60 条

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