Metal-free 1,3-dipolar cyclization of azides with HFO-1233zd(E) in the presence of amines: one-step regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives

被引：6

作者：

Wang, Jing ^{[1
,2
]}

Yu, Qian ^{[1
,2
]}

Wang, Zheng ^{[1
,2
]}

Zhang, Zheteng ^{[2
]}

Zeng, Linghui ^{[2
]}

Zhang, Chong ^{[2
]}

Zhu, Huajian ^{[1
,2
]}

Shao, Jiaan ^{[1
,2
]}

Zhang, Jiankang ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China

[2] Hangzhou City Univ, Sch Med, Key Lab Novel Targets & Drug Study Neural Repair Z, Hangzhou 310015, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 12期

关键词：

ORGANIC AZIDES; CYCLOADDITION; ALKYLATION; LIGATION;

D O I：

10.1039/d3qo00333g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and metal-free strategy for the regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives was developed by employing azides, HFO-1233zd(E) and amines in an aqueous reaction medium. The defluorinative functionalization of the C(sp(3))-F bond in the trifluoromethyl group into amides was involved in the reaction process.

引用

页码：3016 / 3020

页数：5

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