The International Prognostic Score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma

被引：1

作者：

Simba, Kudakwashe ^{[1
,2
]}

Mohamed, Zainab ^{[2
,3
]}

Opie, Jessica J. ^{[2
,4
]}

Andera, Lillian F. ^{[1
,2
]}

Brown, Karryn ^{[1
,2
]}

Oosthuizen, Jenna ^{[1
,2
]}

Antel, Katherine ^{[1
,2
]}

Dawood, Tareen ^{[5
]}

Van der Vyfer, Lydia ^{[1
,2
]}

Du Toit, Cecile ^{[1
,2
]}

Louw, Vernon J. ^{[1
,2
]}

Verburgh, Estelle ^{[1
,2
]}

机构：

[1] Univ Cape Town, Dept Med, Div Clin Haematol, Cape Town, South Africa

[2] Groote Schuur Hosp, Cape Town, South Africa

[3] Univ Cape Town, Dept Radiat Oncol, Cape Town, South Africa

[4] Univ Cape Town, Dept Pathol, Natl Hlth Lab Serv, Div Haematol, Cape Town, South Africa

[5] Univ Cape Town, Dept Human Biol, Div Biomed Engn, Cape Town, South Africa

来源：

LEUKEMIA & LYMPHOMA | 2023年 / 64卷 / 03期

关键词：

Hodgkin lymphoma; transfusion; anemia; IPS; HIV; BONE-MARROW INVOLVEMENT; TREATMENT OUTCOMES; CANCER; CHEMOTHERAPY; FEATURES; THERAPY; DISEASE; ANEMIA; BLOOD; ABVD;

D O I：

10.1080/10428194.2022.2157214

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the burden of anemia among Hodgkin lymphoma (HL) patients, data evaluating red cell concentrate transfusion are limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line adriamycin, bleomycin sulfate, vinblastine sulfate, and dacarbazine (ABVD) treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39.5% and 74.2% of patients had advanced stage HL. Patient prognosis was scored using the HL International Prognostic Score (IPS-7) and HL IPS-3. Seventy (24.6%) patients were transfused with a median of 2 (IQR 1-5) units per patient. Compared to HIV-negative patients, more HIV-positive patients were transfused (14.1% vs. 40.4%, p < .001) and received more units, median 2 (IQR 1-3) vs. 3 (IQR 2-5), p = .035. HL IPS-7 (OR 2.1, p < .001) and HL IPS-3 (OR 2.6, p < .001) were independently associated with transfusion. HL IPS-7, HL IPS-3, and HIV positivity remained associated with transfusion after adjusting for covariates. For patients with newly diagnosed HL, HL IPS-7, HL IPS-3, and HIV status predicted transfusion.

引用

页码：613 / 620

页数：8

共 39 条

[1]

Ali Sheeraz, 2015, J Ayub Med Coll Abbottabad, V27, P70

[2]

[Anonymous], 2021, HIV AIDS S AFRICA

[3] Diagnosing lymphoma in the shadow of an epidemic: lessons learned from the diagnostic challenges posed by the dual tuberculosis and HIV epidemics [J].

Antel, Katherine ;

Louw, Vernon Johan ;

Maartens, Gary ;

Oosthuizen, Jenna ;

Verburgh, Estelle .

LEUKEMIA & LYMPHOMA, 2020, 61 (14) :3417-3421

[4] The determinants and impact of diagnostic delay in lymphoma in a TB and HIV endemic setting [J].

Antel, Katherine ;

Levetan, Carly ;

Mohamed, Zainab ;

Louw, Vernon J. ;

Oosthuizen, Jenna ;

Maartens, Gary ;

Verburgh, Estelle .

BMC CANCER, 2019, 19 (1)

[5] High Risk Features Contrast With Favorable Outcomes in HIV-associated Hodgkin Lymphoma in the Modern cART Era, ANRS CO16 LYMPHOVIR Cohort [J].

Besson, Caroline ;

Lancar, Remi ;

Prevot, Sophie ;

Brice, Pauline ;

Meyohas, Marie-Caroline ;

Marchou, Bruno ;

Gabarre, Jean ;

Bonnet, Fabrice ;

Goujard, Cecile ;

Lambotte, Olivier ;

Boue, Francois ;

Mounier, Nicolas ;

Partisani, Marialuisa ;

Raffi, Francois ;

Costello, Regis ;

Hendel-Chavez, Houria ;

Algarte-Genin, Michele ;

Trabelsi, Selma ;

Marchand, Lucie ;

Raphael, Martine ;

Taoufik, Yassine ;

Costagliola, Dominique .

CLINICAL INFECTIOUS DISEASES, 2015, 61 (09) :1469-1475

[6] Treatment outcomes for Hodgkin lymphoma: First report from the Brazilian Prospective Registry [J].

Biasoli, Irene ;

Castro, Nelson ;

Delamain, Marcia ;

Silveira, Talita ;

Farley, James ;

Simoes, Belinda Pinto ;

Solza, Cristiana ;

Praxedes, Monica ;

Baiocchi, Otavio ;

Gaiolla, Rafael ;

Franceschi, Fernanda ;

Sola, Caroline Bonamin ;

Boquimpani, Carla ;

Clementino, Nelma ;

Perini, Guilherme ;

Pagnano, Katia ;

Steffenello, Giovanna ;

Tabacof, Jacques ;

Colli, Gilberto de Freitas ;

Soares, Andrea ;

de Souza, Carmino ;

Chiattone, Carlos Sergio ;

Milito, Cristiane ;

Morais, Jose Carlos ;

Spector, Nelson .

HEMATOLOGICAL ONCOLOGY, 2018, 36 (01) :189-195

[7] Evaluation of anaemia in patients with multiple myeloma and lymphoma:: findings of the European CANCER ANAEMIA SURVEY [J].

Birgegard, Gunnar ;

Gascon, Pere ;

Ludwig, Heinz .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2006, 77 (05) :378-386

[8] Clinical features and treatment outcomes of Hodgkin lymphoma: A retrospective review in a Malaysian tertiary hospital [J].

Boo, Yang Liang ;

Ting, Helen Siew Yean ;

Yap, Diana Fui Sing ;

Toh, See Guan ;

Lim, Soo Min .

BLOOD RESEARCH, 2019, 54 (03) :210-217

[9] Karnofsky and ECOG performance status scoring in lung cancer: A prospective, longitudinal study of 536 patients from a single institution [J].

Buccheri, G ;

Ferrigno, D ;

Tamburini, M .

EUROPEAN JOURNAL OF CANCER, 1996, 32A (07) :1135-1141

[10]

Campo E., 2017, WHO classification of tumours of haematopoietic and lymphoid tissues revised 4th edition: 2. WHO classification of tumours of haematopoietic and lymphoid tissues revised 4th edition, V4th

← 1 2 3 4 →