The Role of Vasculature and Angiogenic Strategies in Bone Regeneration

被引：18

作者：

Jang, Hye-Jeong ^{[1
]}

Yoon, Jeong-Kee ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Syst Biotechnol, Anseong 17546, Gyeonggi Do, South Korea

来源：

BIOMIMETICS | 2024年 / 9卷 / 02期

关键词：

angiogenesis; bone regeneration; osteogenesis; vasculature; BETA-TRICALCIUM PHOSPHATE; ENDOTHELIAL GROWTH-FACTOR; TOTAL HIP-ARTHROPLASTY; CRITICAL SIZE DEFECT; MECHANICAL-PROPERTIES; EXPERIMENTAL-MODEL; BLOOD-VESSELS; DUAL DELIVERY; SCAFFOLDS; HYDROXYAPATITE;

D O I：

10.3390/biomimetics9020075

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Bone regeneration is a complex process that involves various growth factors, cell types, and extracellular matrix components. A crucial aspect of this process is the formation of a vascular network, which provides essential nutrients and oxygen and promotes osteogenesis by interacting with bone tissue. This review provides a comprehensive discussion of the critical role of vasculature in bone regeneration and the applications of angiogenic strategies, from conventional to cutting-edge methodologies. Recent research has shifted towards innovative bone tissue engineering strategies that integrate vascularized bone complexes, recognizing the significant role of vasculature in bone regeneration. The article begins by examining the role of angiogenesis in bone regeneration. It then introduces various in vitro and in vivo applications that have achieved accelerated bone regeneration through angiogenesis to highlight recent advances in bone tissue engineering. This review also identifies remaining challenges and outlines future directions for research in vascularized bone regeneration.

引用

页数：19

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