Green oxidative cyclization to access 2,5-disubstituted-1,3,4-oxadiazoles from aldehydes and hydrazide derivatives using FeBr3 catalyst and hydrogen peroxide

被引：2
|
作者：
Wang, Jian [1 ]
Wang, Linyang [2 ]
Qin, Huilin [2 ]
Tian, Ruotong [2 ]
Pan, Yuliang [2 ]
机构：
[1] Fujian Normal Univ, Coll Chem & Mat Sci, Fuzhou 350007, Peoples R China
[2] Taizhou Univ, Sch Pharmaceut Sci, Taizhou 318000, Peoples R China
来源：
TETRAHEDRON LETTERS | 2023年 / 131卷
关键词：
Oxidative Cyclization; Iron(III) bromide catalyst; Hydrogen peroxide; ONE-POT SYNTHESIS; N-ACYLHYDRAZONES; 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES; OXADIAZOLES; RALTEGRAVIR; HYDRAZONES; INHIBITORS; ACIDS;
D O I：
10.1016/j.tetlet.2023.154783
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2,5-disubstituted-1,3,4-oxadiazoles Oxidative cyclization of aldehydes and hydrazide derivatives to access 2,5disubstituted-1,3,4-oxadiazoles has been developed using a catalytic amount of FeBr3 in the presence of aqueous hydrogen peroxide as an oxidant. By synthesizing 35 examples of 2,5-disubstituted 1,3,4-oxadiazoles, this approach was demonstrated to have good features including broad scope, mild conditions, air/water tolerance, and simple operation. More importantly, it can be expected to find wide applications in organic synthesis.
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页数：5
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