Green oxidative cyclization to access 2,5-disubstituted-1,3,4-oxadiazoles from aldehydes and hydrazide derivatives using FeBr3 catalyst and hydrogen peroxide

被引：2

作者：

Wang, Jian ^{[1
]}

Wang, Linyang ^{[2
]}

Qin, Huilin ^{[2
]}

Tian, Ruotong ^{[2
]}

Pan, Yuliang ^{[2
]}

机构：

[1] Fujian Normal Univ, Coll Chem & Mat Sci, Fuzhou 350007, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut Sci, Taizhou 318000, Peoples R China

来源：

TETRAHEDRON LETTERS | 2023年 / 131卷

关键词：

Oxidative Cyclization; Iron(III) bromide catalyst; Hydrogen peroxide; ONE-POT SYNTHESIS; N-ACYLHYDRAZONES; 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES; OXADIAZOLES; RALTEGRAVIR; HYDRAZONES; INHIBITORS; ACIDS;

D O I：

10.1016/j.tetlet.2023.154783

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,5-disubstituted-1,3,4-oxadiazoles Oxidative cyclization of aldehydes and hydrazide derivatives to access 2,5disubstituted-1,3,4-oxadiazoles has been developed using a catalytic amount of FeBr3 in the presence of aqueous hydrogen peroxide as an oxidant. By synthesizing 35 examples of 2,5-disubstituted 1,3,4-oxadiazoles, this approach was demonstrated to have good features including broad scope, mild conditions, air/water tolerance, and simple operation. More importantly, it can be expected to find wide applications in organic synthesis.

引用

页数：5

共 36 条

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