Roles of non-coding RNAs in cell death pathways involved in the treatment of resistance and recurrence of cancer

被引：6

作者：

Motlagh, Fatemeh Movahedi ^{[1
,2
]}

Kadkhoda, Sepideh ^{[1
]}

Motamedrad, Maryam ^{[3
,4
]}

Javidzade, Parisa ^{[5
]}

Khalilian, Sheyda ^{[6
,7
]}

Modarressi, Mohammad Hossein ^{[1
]}

Ghafouri-Fard, Soudeh ^{[7
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[2] Sabzevar Univ Med Sci, Cellular & Mol Res Ctr, Sabzevar, Iran

[3] Univ Alberta, Div Human Nutr, Edmonton, AB T6G 2P5, Canada

[4] Univ Birjand, Fac Sci, Dept Biol, Birjand, Iran

[5] Shahid Chamran Univ Ahvaz, Fac Sci, Dept Genet, Ahvaz, Iran

[6] Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Med, Tehran, Iran

[7] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 247卷

关键词：

Cancer recurrence; Noncoding RNA; Drug resistance; Cell death; COMPETING ENDOGENOUS RNA; MULTIDRUG-RESISTANCE; TUMOR-SUPPRESSOR; TARGETING BCL2; APOPTOSIS; EXPRESSION; AUTOPHAGY; PROLIFERATION; MICRORNA; CHEMORESISTANCE;

D O I：

10.1016/j.prp.2023.154542

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Considering the burden of cancer, a number of methods have been applied to control or stop it. However, because of drug resistance or cancer recurrence, these treatments usually face failure. Combination of modulation of expression of non-coding RNAs (ncRNAs) with other treatments can increase treatment-sensitivity of tumors but these approaches still face some challenges. Gathering information in this field is a prerequisite to find more efficient cures for cancer. Cancer cells use ncRNAs to enhance uncontrolled proliferation originated from inac-tivation of cell death routs. In this review article, the main routes of cell death and involved ncRNAs in these routes are discussed. Moreover, extant information in the role of different ncRNAs on cell death pathways involved in the treatment resistance and cancer recurrence is summarized.

引用

页数：12

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