The Role of Oxidative Stress and Antioxidants in Cardiovascular Comorbidities in COPD

被引:11
作者
Miklos, Zsuzsanna [1 ]
Horvath, Ildiko [1 ,2 ]
机构
[1] Natl Korany Inst Pulmonol, Korany F St 1, H-1121 Budapest, Hungary
[2] Univ Debrecen, Dept Pulmonol, Nagyerde krt 98, H-4032 Debrecen, Hungary
关键词
antioxidants; arterial aging; airway inflammation; & alpha; -Klotho; ROS; hydrogen peroxide; SOD; heart rate variability; OBSTRUCTIVE PULMONARY-DISEASE; HEART-RATE-VARIABILITY; EXHALED BREATH CONDENSATE; LOW-DENSITY-LIPOPROTEIN; NF-KAPPA-B; EPITHELIAL-CELL SENESCENCE; MOUSE KLOTHO GENE; ARTERIAL STIFFNESS; LUNG-FUNCTION; GLUTATHIONE PEROXIDASE-1;
D O I
10.3390/antiox12061196
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oxidative stress driven by several environmental and local airway factors associated with chronic obstructive bronchiolitis, a hallmark feature of COPD, plays a crucial role in disease pathomechanisms. Unbalance between oxidants and antioxidant defense mechanisms amplifies the local inflammatory processes, worsens cardiovascular health, and contributes to COPD-related cardiovascular dysfunctions and mortality. The current review summarizes recent developments in our understanding of different mechanisms contributing to oxidative stress and its countermeasures, with special attention to those that link local and systemic processes. Major regulatory mechanisms orchestrating these pathways are also introduced, with some suggestions for further research in the field.
引用
收藏
页数:29
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