Impact of interstitial lung abnormalities on postoperative pulmonary complications and survival of lung cancer

被引:16
作者
Im, Yunjoo [1 ]
Chung, Man Pyo [1 ]
Lee, Kyung Soo [2 ]
Han, Joungho [3 ]
Chung, Myung Jin [4 ,5 ]
Kim, Hong Kwan [6 ]
Cho, Jong Ho [6 ]
Choi, Yong Soo [6 ]
Park, Sujin [3 ]
Kim, Ho Joong [1 ]
Kwon, O. Jung [1 ]
Park, Boram [7 ]
Yoo, Hongseok [1 ]
机构
[1] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Pulm & Crit Care Med,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea
[2] Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Radiol, Sch Med, Seoul, South Korea
[3] Sungkyunkwan Univ, Samsung Med Ctr, Dept Pathol, Sch Med, Seoul, South Korea
[4] Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiol, Sch Med, Seoul, South Korea
[5] Sungkyunkwan Univ, Samsung Med Ctr, Ctr Imaging Sci, Sch Med, Seoul, South Korea
[6] Sungkyunkwan Univ, Samsung Med Ctr, Dept Thorac Surg, Sch Med, Seoul, South Korea
[7] Samsung Med Ctr, Biomed Stat Ctr, Res Inst Future Med, Seoul, South Korea
关键词
interstitial fibrosis; lung cancer; thoracic surgery; ACUTE EXACERBATION; FIBROSIS; SMOKING; RISK; CLASSIFICATION; PNEUMONIA; FEATURES; OUTCOMES; DISEASE; SURGERY;
D O I
10.1136/thoraxjnl-2021-218055
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background Interstitial lung abnormalities (ILAs) are associated with the risk of lung cancer and its mortality. However, the impact of ILA on treatment-related complications and survival in patients who underwent curative surgery is still unknown. Research question This study aimed to evaluate the significance of the presence of computed tomography-diagnosed ILA and histopathologically matched interstitial abnormalities on postoperative pulmonary complications (PPCs) and the long-term survival of patients who underwent surgical treatment for lung cancer. Study design and methods A matched case-control study was designed to compare PPCs and mortality among 50 patients with ILA, 50 patients with idiopathic pulmonary fibrosis (IPF) and 200 controls. Cases and controls were matched by sex, age, smoking history, tumour location, the extent of surgery, tumour histology and pathological TNM stage. Results Compared with the control group, the OR of the prevalence of PPCs increased to 9.56 (95% CI 2.85 to 32.1, p<0.001) in the ILA group and 56.50 (95% CI 17.92 to 178.1, p<0.001) in the IPF group. The 5-year overall survival (OS) rates of the control, ILA and IPF groups were 76% (95% CI 71% to 83%), 52% (95% CI 37% to 74%) and 32% (95% CI 19% to 53%), respectively (log-rank p<0.001). Patients with ILA had better 5-year OS than those with IPF (log-rank p=0.046) but had worse 5-year OS than those in the control group (log-rank p=0.002). Conclusions The presence of radiological and pathological features of ILA in patients with lung cancer undergoing curative surgery was associated with frequent complications and decreased survival.
引用
收藏
页码:183 / 190
页数:8
相关论文
共 47 条
[1]   A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications [J].
Abbott, T. E. F. ;
Fowler, A. J. ;
Pelosi, P. ;
de Abreu, M. Gama ;
Moller, A. M. ;
Canet, J. ;
Creagh-Brown, B. ;
Mythen, M. ;
Gin, T. ;
Lalu, M. M. ;
Futier, E. ;
Grocott, M. P. ;
Schultz, M. J. ;
Pearse, R. M. .
BRITISH JOURNAL OF ANAESTHESIA, 2018, 120 (05) :1066-1079
[2]   Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia with and without Concurrent Emphysema: Thin-Section CT Findings [J].
Akira, Masanori ;
Inoue, Yoshikazu ;
Kitaichi, Masanori ;
Yamamoto, Satoru ;
Arai, Toru ;
Toyokawa, Kazushige .
RADIOLOGY, 2009, 251 (01) :271-279
[3]  
[Anonymous], 2017, PNEUMOLOGIE, V71, P9
[4]   Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study [J].
Araki, Tetsuro ;
Putman, Rachel K. ;
Hatabu, Hiroto ;
Gao, Wei ;
Dupuis, Josee ;
Latourelle, Jeanne C. ;
Nishino, Mizuki ;
Zazueta, Oscar E. ;
Kurugol, Sila ;
Ross, James C. ;
Estepar, Raul San Jose ;
Schwartz, David A. ;
Rosas, Ivan O. ;
Washko, George R. ;
O'Connor, George T. ;
Hunninghake, Gary M. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 194 (12) :1514-1522
[5]   The associations of interstitial lung abnormalities with cancer diagnoses and mortality [J].
Axelsson, Gisli T. ;
Putman, Rachel K. ;
Aspelund, Thor ;
Gudmundsson, Elias F. ;
Hida, Tomayuki ;
Araki, Tetsuro ;
Nishino, Mizuki ;
Hatabu, Hiroto ;
Gudnason, Vilmundur ;
Hunninghake, Gary M. ;
Gudmundsson, Gunnar .
EUROPEAN RESPIRATORY JOURNAL, 2020, 56 (06)
[6]   Preoperative smoking habits and postoperative pulmonary complications [J].
Bluman, LG ;
Mosca, L ;
Newman, N ;
Simon, DG .
CHEST, 1998, 113 (04) :883-889
[7]   Interstitial Lung Abnormalities and Lung Cancer Risk in the National Lung Screening Trial [J].
Brown, Stacey-Ann Whittaker ;
Padilla, Maria ;
Mhango, Grace ;
Powell, Charles ;
Salvatore, Mary ;
Henschke, Claudia ;
Yankelevitz, David ;
Sigel, Keith ;
De-Torres, Juan P. ;
Wisnivesky, Juan .
CHEST, 2019, 156 (06) :1195-1203
[8]   Early corticosteroid treatment for postoperative acute lung injury after lung cancer surgery [J].
Choi, Hayoung ;
Shin, Beomsu ;
Yoo, Hongseok ;
Suh, Gee Young ;
Cho, Jong Ho ;
Kim, Hong Kwan ;
Choi, Yong Soo ;
Kim, Jhingook ;
Zo, Jae Ill ;
Shim, Young Mog ;
Jeon, Kyeongman .
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, 2019, 13
[9]   Acute Exacerbation of Idiopathic Pulmonary Fibrosis An International Working Group Report [J].
Collard, Harold R. ;
Ryerson, Christopher J. ;
Corte, Tamera J. ;
Jenkins, Gisli ;
Kondoh, Yasuhiro ;
Lederer, David J. ;
Lee, Joyce S. ;
Maher, Toby M. ;
Wells, Athol U. ;
Antoniou, Katerina M. ;
Behr, Juergen ;
Brown, Kevin K. ;
Cottin, Vincent ;
Flaherty, Kevin R. ;
Fukuoka, Junya ;
Hansell, David M. ;
Johkoh, Takeshi ;
Kaminski, Naftali ;
Kim, Dong Soon ;
Kolb, Martin ;
Lynch, David A. ;
Myers, Jeffrey L. ;
Raghu, Ganesh ;
Richeldi, Luca ;
Taniguchi, Hiroyuki ;
Martinez, Fernando J. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 194 (03) :265-275
[10]   Acute lung injury in thoracic surgery [J].
Della Rocca, Giorgio ;
Coccia, Cecilia .
CURRENT OPINION IN ANESTHESIOLOGY, 2013, 26 (01) :40-46