The ethics of clinical research in the era of COVID-19

被引：0

作者：

Vitti, Juliana N. ^{[1
]}

Vitti, Robert ^{[2
]}

Chu, Karen ^{[2
]}

Mellis, Scott ^{[2
]}

机构：

[1] Boston Univ, Boston, MA USA

[2] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA

来源：

FRONTIERS IN PUBLIC HEALTH | 2024年 / 12卷

关键词：

clinical trial conduct; COVID-19; therapeutics; vaccines; biospecimens; ethics; -; clinical; CONSENT;

D O I：

10.3389/fpubh.2024.1359654

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

There is an urgent need for increased understanding of COVID-19 and strategies for its prevention, treatment, and mitigation. All participants in the research enterprise, including institutional review boards, have an ethical duty to protect participants and ensure that the benefits gained from such research do not conflict with the core principles that guided researchers prior to the pandemic. In this review, we discuss the ethical issues surrounding initiation and conduct of clinical trials, focusing on novel COVID-19 therapeutic, vaccine, or biospecimen research, using the principles of autonomy, beneficence, and justice. We discuss strategies to manage the practical challenges associated with the conduct of clinical trials, with an emphasis on maintaining the rights and welfare of research participants.

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页数：7

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