Anti-vascular endothelial growth factor receptor in colorectal cancer: A review

被引：0

作者：

Colombo, Alfredo ^{[1
,2
]}

Porretto, Concetta Maria ^{[1
]}

机构：

[1] CDC Macchiarella, Med Oncol Unit, Palermo, Italy

[2] CDC Macchiarella, Med Oncol Unit, Viale Regina Margher 25, I-90141 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF GASTROINTESTINAL INTERVENTION | 2023年 / 12卷 / 03期

关键词：

Colorectal neoplasm; Drug therapy; ErbB receptors; Neoplasms; Vascular endothelial growth factor A; AFLIBERCEPT VEGF-TRAP; ORAL FLUOROPYRIMIDINES; CLINICAL-APPLICATIONS; 1ST-LINE TREATMENT; CONTROLLED-TRIAL; FACTOR PATHWAY; PHASE-II; BEVACIZUMAB; THERAPY; TUMOR;

D O I：

10.18528/ijgii230011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In recent years, the treatment of metastatic colorectal cancer (mCRC) has dramatically changed thanks to the advent of new drugs called molecular targeted therapies such as anti-vascular endothelial growth factor (anti-VEGF) and anti-epidermal growth factor (anti-EGFR). Bevacizumab, afliber-cept and ramucirumab which belong to the first category, have been used for many years in clinical practice, achieving improvements in progres-sion-free survival and overall survival in many phase III trials. These agents act by blocking the growth of the tumor vascular bed via the inhibition of neoangiogenesis. This review summarizes all available data in the literature on bevacizumab, aflibercept, and ramucirumab and describes their use in the continuum of care of mCRC.Copyright & COPY; 2023, Society of Gastrointestinal Intervention.

引用

页码：110 / 114

页数：5

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