Gut microbiota and its metabolites in depression: from pathogenesis to treatment

被引：332

作者：

Liu, Lanxiang ^{[1
,2
,3
]}

Wang, Haiyang ^{[2
,4
,5
]}

Chen, Xueyi ^{[2
]}

Zhang, Yangdong ^{[2
,3
]}

Zhang, Hanping ^{[2
,3
]}

Xie, Peng ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Chongqing Med Univ, Dept Neurol, Yongchuan Hosp, Chongqing 402160, Peoples R China

[2] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing 400016, Peoples R China

[3] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China

[4] Chongqing Med Univ, Coll Stomatol, Chongqing 401147, Peoples R China

[5] Chongqing Med Univ, Affiliated Stomatol Hosp, Chongqing 401147, Peoples R China

[6] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China

来源：

EBIOMEDICINE | 2023年 / 90卷

关键词：

Gut microbiota; Metabolites; Depression; Pathogenesis; Microbial -targeted therapeutics; DOUBLE-BLIND; INTESTINAL MICROBIOTA; VAGUS NERVE; DISORDER; TRANSPLANTATION; ANXIETY; RISK; TRANSLOCATION; BEHAVIORS; DYSBIOSIS;

D O I：

10.1016/j.ebiom.2023.104527

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Major depressive disorder is one of the most disabling mental disorders worldwide. Increasing preclinical and clinical studies have highlighted that compositional and functional (e.g., metabolite) changes in gut microbiota, known as dysbiosis, are associated with the onset and progression of depression via regulating the gut-brain axis. However, the gut microbiota and their metabolites present a double-edged sword in depression. Dysbiosis is involved in the pathogenesis of depression while, at the same time, offering a novel therapeutic target. In this review, we describe the association between dysbiosis and depression, drug-microbiota interactions in antidepressant treatment, and the potential health benefits of microbial-targeted therapeutics in depression, including dietary interventions, fecal microbiota transplantation, probiotics, prebiotics, synbiotics, and postbiotics. With the emergence of microbial research, we describe a new direction for future research and clinical treatment of depression.

引用

页数：13

共 116 条

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