Aim: Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress occurring in delayed clearance of lung fluid. This is the first report to examine thiol-disulfide homeostasis in patients with TTN.Material and Methods: Thirty TTN and 30 controls were included in the present study. The dynamic thiol-disulfide balance was determined by the new colorimetric method developed by Erel et al. TAS, TOS and OSI levels were evaluated using the previously described method developed by Erel.Results: Thiol levels were found to be significantly lower between patient and the control groups. However, disulfide levels were not significantly higher in the TTN group compared with the control groups. Disulfide/native thiol, disulfide/total thiol and native/total thiol levels were statistically significantly different between the TTN and control groups. Moreover, we found that TAS, TOS and OSI levels were also statistically significantly different between patient and control groups.Discussion: This study indicates that the measurement of dynamic thiol-disulfide homeostasis may contribute to the pathophysiological mechanism, and follow-up of the disease in patients with TTN. In addition, increased TOS and decreased TAS levels may be related with increased oxidative stress and a functional reduction of antioxidant defense system
机构:
Karolinska Inst, Dept Med Biochem & Biophys, Med Nobel Inst Biochem, SE-17177 Stockholm, SwedenKarolinska Inst, Dept Med Biochem & Biophys, Med Nobel Inst Biochem, SE-17177 Stockholm, Sweden
机构:
Istanbul Medeniyet Univ, Dept Biochem, Goztepe Training & Res Hosp, Istanbul, TurkeyIstanbul Medeniyet Univ, Dept Pediat, Div Neonatol, Goztepe Training & Res Hosp, Istanbul, Turkey
机构:
Sanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Cakirca, Gokhan
Celik, Muhammet Murat
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Mustafa Kemal Univ, Fac Med, Dept Internal Med, Antakya, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Celik, Muhammet Murat
Erdal, Huseyin
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Mustafa Kemal Univ, Fac Med, Dept Mol Biochem & Genet, Antakya, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Erdal, Huseyin
Neselioglu, Salim
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Yildirim Beyazit Univ, Dept Biochem, Fac Med, Ankara, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Neselioglu, Salim
Erel, Ozcan
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Yildirim Beyazit Univ, Dept Biochem, Fac Med, Ankara, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Erel, Ozcan
Basarali, Mustafa Kemal
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Ankara Publ Hlth Inst, Dept Biochem, Ankara, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Basarali, Mustafa Kemal
Cakirca, Tuba Damar
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h-index: 0
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Harran Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Sanliurfa, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
机构:
Ankara Yildirim Beyazit Univ, Dept Med Biochem, Fac Med, Ankara, Turkey
Ankara City Hosp, Dept Med Biochem, Ankara, TurkeyAnkara Yildirim Beyazit Univ, Dept Med Biochem, Fac Med, Ankara, Turkey
Erel, Ozcan
Erdogan, Serpil
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Ankara Yildirim Beyazit Univ, Dept Med Biochem, Fac Med, Ankara, TurkeyAnkara Yildirim Beyazit Univ, Dept Med Biochem, Fac Med, Ankara, Turkey
机构:
Karolinska Inst, Dept Med Biochem & Biophys, Med Nobel Inst Biochem, SE-17177 Stockholm, SwedenKarolinska Inst, Dept Med Biochem & Biophys, Med Nobel Inst Biochem, SE-17177 Stockholm, Sweden
机构:
Istanbul Medeniyet Univ, Dept Biochem, Goztepe Training & Res Hosp, Istanbul, TurkeyIstanbul Medeniyet Univ, Dept Pediat, Div Neonatol, Goztepe Training & Res Hosp, Istanbul, Turkey
机构:
Sanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Cakirca, Gokhan
Celik, Muhammet Murat
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h-index: 0
机构:
Mustafa Kemal Univ, Fac Med, Dept Internal Med, Antakya, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Celik, Muhammet Murat
Erdal, Huseyin
论文数: 0引用数: 0
h-index: 0
机构:
Mustafa Kemal Univ, Fac Med, Dept Mol Biochem & Genet, Antakya, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Erdal, Huseyin
Neselioglu, Salim
论文数: 0引用数: 0
h-index: 0
机构:
Yildirim Beyazit Univ, Dept Biochem, Fac Med, Ankara, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Neselioglu, Salim
Erel, Ozcan
论文数: 0引用数: 0
h-index: 0
机构:
Yildirim Beyazit Univ, Dept Biochem, Fac Med, Ankara, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Erel, Ozcan
Basarali, Mustafa Kemal
论文数: 0引用数: 0
h-index: 0
机构:
Ankara Publ Hlth Inst, Dept Biochem, Ankara, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
Basarali, Mustafa Kemal
Cakirca, Tuba Damar
论文数: 0引用数: 0
h-index: 0
机构:
Harran Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Sanliurfa, TurkeySanliurfa Mehmet Akif Inan Training & Res Hosp, Dept Biochem, Sanliurfa, Turkey
机构:
Ankara Yildirim Beyazit Univ, Dept Med Biochem, Fac Med, Ankara, Turkey
Ankara City Hosp, Dept Med Biochem, Ankara, TurkeyAnkara Yildirim Beyazit Univ, Dept Med Biochem, Fac Med, Ankara, Turkey
Erel, Ozcan
Erdogan, Serpil
论文数: 0引用数: 0
h-index: 0
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Ankara Yildirim Beyazit Univ, Dept Med Biochem, Fac Med, Ankara, TurkeyAnkara Yildirim Beyazit Univ, Dept Med Biochem, Fac Med, Ankara, Turkey