Thiol/disulfide homeostasis as a new oxidative stress marker in patients with neonatal transient tachypnea

被引:8
作者
Erdal, Huseyin [1 ]
Demirtas, Mehmet Semih [2 ]
Tuncer, Sibel Cigdem [3 ]
Ozcan, Oguzhan [4 ]
机构
[1] Aksaray Univ, Fac Med, Dept Med Genet, Aksaray, Turkiye
[2] Aksaray Training & Res Hosp, Dept Pediat, Aksaray, Turkiye
[3] Aksaray Univ, Fac Med, Dept Biochem, Aksaray, Turkiye
[4] Hatay Mustafa Kemal Univ, Fac Med, Dept Biochem, Hatay, Turkiye
来源
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE | 2023年 / 14卷 / 03期
关键词
Transient Tachypnea; Oxidative Stress; Thiol; Disulfide Homeostasis; Newborn; Respiratory Distress; RESPIRATORY-DISTRESS; NEWBORN;
D O I
10.4328/ACAM.21457
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim: Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress occurring in delayed clearance of lung fluid. This is the first report to examine thiol-disulfide homeostasis in patients with TTN.Material and Methods: Thirty TTN and 30 controls were included in the present study. The dynamic thiol-disulfide balance was determined by the new colorimetric method developed by Erel et al. TAS, TOS and OSI levels were evaluated using the previously described method developed by Erel.Results: Thiol levels were found to be significantly lower between patient and the control groups. However, disulfide levels were not significantly higher in the TTN group compared with the control groups. Disulfide/native thiol, disulfide/total thiol and native/total thiol levels were statistically significantly different between the TTN and control groups. Moreover, we found that TAS, TOS and OSI levels were also statistically significantly different between patient and control groups.Discussion: This study indicates that the measurement of dynamic thiol-disulfide homeostasis may contribute to the pathophysiological mechanism, and follow-up of the disease in patients with TTN. In addition, increased TOS and decreased TAS levels may be related with increased oxidative stress and a functional reduction of antioxidant defense system
引用
收藏
页码:208 / 211
页数:4
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