Survivin Small Molecules Inhibitors: Recent Advances and Challenges

被引：37

作者：

Albadari, Najah ^{[1
]}

Li, Wei ^{[1
]}

机构：

[1] Univ Tennessee Hlth Sci Ctr, Coll Pharm, Dept Pharmaceut Sci, Memphis, TN 38163 USA

来源：

MOLECULES | 2023年 / 28卷 / 03期

关键词：

survivin; apoptosis; mitosis; chemoresistance; survivin small molecules inhibitors; SEPANTRONIUM BROMIDE YM155; PHOSPHORYLATED HISTONE H3; MULTICENTER PHASE-II; ANTI-APOPTOSIS GENE; BREAST-CANCER CELLS; NORMAL CORD BLOOD; SPLICE VARIANTS; NUCLEAR EXPORT; TARGETING SURVIVIN; ANTITUMOR-ACTIVITY;

D O I：

10.3390/molecules28031376

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a suppressor of apoptosis and plays a central role in cell division. Survivin has been considered as an important cancer drug target because it is highly expressed in many types of human cancers, while it is effectively absent from terminally differentiated normal tissues. Moreover, survivin is involved in tumor cell resistance to chemotherapy and radiation. Preclinically, downregulation of survivin expression or function reduced tumor growth induced apoptosis and sensitized tumor cells to radiation and chemotherapy in different human tumor models. This review highlights the role of survivin in promoting cellular proliferation and inhibiting apoptosis and summarizes the recent advances in and challenges of developing small-molecule survivin inhibitors.

引用

页数：22

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