A review on taste masked multiparticulate dosage forms for paediatric

被引：15
作者：
AL-Japairai, Khater [1 ]
Almurisi, Samah Hamed [2 ]
Doolaanea, Abd Almonem [3 ]
Mahmood, Syed [4 ]
Alheibshy, Fawaz [5 ,6 ]
Alobaida, Ahmed [5 ]
Abdul-Halim, Nadiya [1 ]
Chatterjee, Bappaditya [7 ]
机构：
[1] Univ Malaysia Pahang, Dept Pharmaceut Engn, Fac Chem & Proc Engn Technol, Gambang 26300, Malaysia
[2] Int Islamic Univ Malaysia, Dept Pharmaceut Technol, Kulliyyah Pharm, Kuantan 25200, Malaysia
[3] Kolej Univ Antarabangsa Maiwp UCMI, Dept Pharmaceut Technol, Fac Pharm, Taman Batu Muda,Batu Caves, Kuala Lumpur 68100, Malaysia
[4] Univ Malaya, Fac Pharm, Dept Pharmaceut Technol, Kuala Lumpur 50603, Malaysia
[5] Univ Hail, Coll Pharm, Dept Pharmaceut, Hail, Saudi Arabia
[6] Aden Univ, Coll Pharm, Dept Pharmaceut, Aden, Yemen
[7] SVKMs NMIMS, SPP Sch Pharm & Technol Management, Mumbai, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2023年 / 632卷
关键词：
Paediatric; Unpleasant drug; Taste masking; Multiparticulate system; ORALLY DISINTEGRATING TABLETS; UNCOATED MINI-TABLETS; HOT-MELT EXTRUSION; FORMULATION DEVELOPMENT; MASKING EFFICIENCY; SUSTAINED-RELEASE; DRUG FORMULATIONS; YOUNG-CHILDREN; MEDICINES; ACCEPTABILITY;
D O I：
10.1016/j.ijpharm.2022.122571
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Taste refers to those sensations perceived through taste buds on the tongue and oral cavity. The unpleasant taste of drugs leads to the refusal of taking the medicine in the paediatric population. It is widely known that a pharmaceutical product's general acceptability is the result of numerous contributing components such as swallowability, palatability (taste, flavour, texture, and mouthfeel), appearance, ease of administration, and patient characteristics. Multiparticulate as a dosage form is a platform technology for overcoming paediatrics' incapacity to swallow monolithic dosage forms, masking many medications' inherent nasty taste, and over-coming the obstacles of manufacturing a commercially taste masked dosage form. This review will discuss the considerations that must be taken into account to prepare taste masked multiparticulate dosage forms in the best way for paediatric use.
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页数：16
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