The IL-1 Family and Its Role in Atherosclerosis

被引：31

作者：

Gonzalez, Leticia ^{[1
,2
]}

Rivera, Katherine ^{[1
,3
]}

Andia, Marcelo E. ^{[1
,2
]}

Martinez Rodriguez, Gonzalo ^{[4
]}

机构：

[1] Pontificia Univ Catolica Chile, Ctr Imagenes Biomed, Escuela Med, Dept Radiol, Santiago 3580000, Chile

[2] Pontificia Univ Catolica Chile, Inst Milenio Ingn & Inteligencia Artificial Para, iHLTH, Santiago 7820436, Chile

[3] Pontificia Univ Catolica Chile, Fac Med, Programa Doctorado Ciencias Med, Santiago 3580000, Chile

[4] Pontificia Univ Catolica Chile, Div Enfermedades Cardiovasc, Santiago 3580000, Chile

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 01期

关键词：

interleukin-1; family; inflammation; atherosclerosis; cardiovascular disease; C-REACTIVE PROTEIN; RECEPTOR ACCESSORY PROTEIN; NF-KAPPA-B; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; BLOOD MONONUCLEAR-CELLS; LONG-TERM MORTALITY; NLRP3; INFLAMMASOME; CARDIOVASCULAR-DISEASE; IFN-GAMMA;

D O I：

10.3390/ijms24010017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The IL-1 superfamily of cytokines is a central regulator of immunity and inflammation. The family is composed of 11 cytokines (with agonist, antagonist, and anti-inflammatory properties) and 10 receptors, all tightly regulated through decoy receptor, receptor antagonists, and signaling inhibitors. Inflammation not only is an important physiological response against infection and injury but also plays a central role in atherosclerosis development. Several clinical association studies along with experimental studies have implicated the IL-1 superfamily of cytokines and its receptors in the pathogenesis of cardiovascular disease. Here, we summarize the key features of the IL-1 family, its role in immunity and disease, and how it helps shape the development of atherosclerosis.

引用

页数：25

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