Elevated soluble urokinase plasminogen activator receptor is associated with renal dysfunction in a Chlorocebus atheiops COVID-19 model

被引：3

作者：

Gonzalez, Alexis A. ^{[1
]}

Olsen, Emily L. ^{[2
,3
]}

Killeen, Stephanie Z. ^{[3
]}

Blair, Robert, V ^{[3
]}

Seshan, Surya, V ^{[4
]}

Jaimes, Edgar A. ^{[5
]}

Roy, Chad J. ^{[2
,3
]}

Prieto, Minolfa C. ^{[6
,7
]}

机构：

[1] Pontificia Univ Catolica Valparaiso, Inst Quim, Valparaiso, Chile

[2] Tulane Sch Med, Dept Microbiol & Immunol, New Orleans, LA USA

[3] Tulane Natl Primate Res Ctr, Covington, LA USA

[4] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY USA

[5] Mem Sloan Kettering Canc Ctr, Renal Serv, New York, NY 10021 USA

[6] Tulane Univ, Sch Med, Dept Physiol, New Orleans, LA 70112 USA

[7] Tulane Univ, Sch Med, Tulane Renal Hypertens Ctr Excellence, New Orleans, LA 70112 USA

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 2023年 / 52卷 / 02期

关键词：

acute kidney injury; African green monkey; nonhuman primate; renal injury; SARS-CoV-2; SUPAR;

D O I：

10.1111/jmp.12626

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Increases of soluble urokinase plasminogen activator receptor (suPAR) were measured in both urine and plasma of a Chlorocebus aethiops (African green monkey; AGM) mucosal infected with SARS-CoV-2. The data indicate that elevated suPAR may be associated with renal dysfunction and pathology in the context of COVID-19.

引用

页码：131 / 134

页数：4

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