Single-cell RNA sequencing to understand host-virus interactions

被引：3

作者：

Chang, Jia-Tong ^{[1
]}

Liu, Li -Bo ^{[1
]}

Wang, Pei -Gang ^{[1
]}

An, Jing ^{[1
]}

机构：

[1] Capital Med Univ, Sch Basic Med Sci, Dept Microbiol, Beijing 100069, Peoples R China

来源：

VIROLOGICA SINICA | 2024年 / 39卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Single -cell RNA sequencing (scRNA-seq); Host -virus interaction; COVID-19; Flavivirus;

D O I：

10.1016/j.virs.2023.11.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Single -cell RNA sequencing (scRNA-seq) has allowed for the profiling of host and virus transcripts and host -virus interactions at single -cell resolution. This review summarizes the existing scRNA-seq technologies together with their strengths and weaknesses. The applications of scRNA-seq in various virological studies are discussed in depth, which broaden the understanding of the immune atlas, host -virus interactions, and immune repertoire. scRNA-seq can be widely used for virology in the near future to better understand the pathogenic mechanisms and discover more effective therapeutic strategies.

引用

页码：1 / 8

页数：8

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