Isolation and Characterization of Antimicrobial Metabolites from the Sophora tonkinensis-Associated Fungus Penicillium sp. GDGJ-N37

被引：6
作者：
Huang, Lili [1 ]
Li, Yongxia [1 ]
Pang, Jing [1 ]
Lv, Liuxia [1 ]
Zhou, Jiatong [1 ]
Liang, Liqi [1 ]
He, Xianhua [1 ]
Li, Jun [1 ]
Xu, Weifeng [1 ]
Yang, Ruiyun [1 ]
机构：
[1] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
来源：
MOLECULES | 2024年 / 29卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Sophora tonkinensis; Penicillium sp; azaphilone derivatives; antibacterial activities; antifungal activities; ENDOPHYTIC FUNGUS; AZAPHILONES; POLYKETIDES; CHEMISTRY; SEA;
D O I：
10.3390/molecules29020348
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemical investigation of Penicillium sp. GDGJ-N37, a Sophora tonkinensis-associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine (1) and 7-methoxyl-N-isoamylsclerotiorinamine (2), and four known azaphilones (3-6), together with two new chromone derivatives, penithochromones X and Y (7 and 8). Their structures were elucidated based on spectroscopic data, CD spectrum, and semi-synthesis. Sclerotioramine (3) showed significant antibacterial activities against B. subtilis and S. dysentery, and it also showed most potent anti-plant pathogenic fungi activities against P. theae, C. miyabeanus, and E. turcicum.
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页数：10
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