Epigenetic drugs as new emerging therapeutics: What is the scale's orientation of application and challenges?

被引：6

作者：

Farani, Marzieh Ramezani ^{[1
]}

Sarlak, Maryam ^{[2
]}

Gholami, Amir ^{[3
]}

Azaraian, Maryam ^{[4
,5
]}

Binabaj, Maryam Moradi ^{[6
,7
]}

Kakavandi, Sareh ^{[8
]}

Tambuwala, Murtaza M. ^{[9
]}

Taheriazam, Afshin ^{[10
,11
]}

Hashemi, Mehrdad ^{[11
,12
]}

Ghasemi, Sorayya ^{[13
]}

机构：

[1] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Pharmaceut Sci Res Ctr PSRC, Toxicol & Dis Grp TDG, Tehran 1417614411, Iran

[2] Portland State Univ, Dept Chem, Portland, OR USA

[3] Kurdistan Univ Med Sci, Student Res Comm, Sanandaj, Iran

[4] Charite Univ Med Berlin, Dept Radiol, D-10117 Berlin, Germany

[5] UFZ Helmholtz Ctr Environm Res, Dept Bioanalyt Ecotoxicol, Leipzig, Germany

[6] Sabzevar Univ Med Sci, Sch Med, Dept Biochem & Nutr, Clin Biochem, Sabzevar, Iran

[7] Sabzevar Univ Med Sci, Cellular & Mol Res Ctr, Sabzevar, Iran

[8] Shiraz Univ Med Sci, Sch Med, Dept Bacteriol & Virol, Shiraz, Iran

[9] Univ Lincoln, Lincoln Med Sch, Brayford Pool, Lincoln, New Zealand

[10] Islamic Azad Univ, Fac Med, Dept Orthoped, Tehran Med Sci, Tehran, Iran

[11] Islamic Azad Univ, Farhikhtegan Hosp Tehran Med Sci, Farhikhtegan Med Convergence Sci Res Ctr, Tehran, Iran

[12] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Genet, Tehran Med Sci, Tehran, Iran

[13] Shahrekord Univ Med Sci, Canc Res Ctr, Shahrekord, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 248卷

关键词：

Epigenetic drugs; Cancer; Epigenetic therapies; Combination therapy; HISTONE DEACETYLASE INHIBITOR; DNA METHYLTRANSFERASE INHIBITORS; EPITHELIAL-MESENCHYMAL TRANSITION; ENDOPLASMIC-RETICULUM STRESS; PANCREATIC-CANCER CELLS; HIGH-DOSE CHEMOTHERAPY; CLASS-I; HDAC INHIBITOR; STEM-CELLS; PROMOTER HYPERMETHYLATION;

D O I：

10.1016/j.prp.2023.154688

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Epigenetics is the study of heritable changes in gene expression or function without altering the DNA sequence. Important factors are part of epigenetic events, such as methylation, DNA histone rearrangements, nucleosome transposition, and non-coding RNAs. Dysregulated epigenetic mechanics are associated with various cancers' initiation, development, and metastasis. It is known that the occurrence and development of cancer can be controlled by regulating unexpected epigenetic events. Epi-drugs are used singly or in combination with chemotherapy and enhance antitumor activity, reduce drug resistance, and stimulate the host immune response. Despite these benefits, epigenetic therapy as a single therapy or in combination with other drugs leads to adverse effects. This review article introduces and compares the advantages, disadvantages, and side effects of using these drugs for the first time since their introduction. Also, this article describes the mechanism of action of various epigenetic drugs. Recommendations for future use of epigenetic drugs as cancer therapeutics are suggested as an overall conclusion.

引用

页数：17

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