Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation

被引：20

作者：

Lee, Seung Cho ^{[1
]}

Adams, Dexter W. ^{[2
,3
]}

Ipsaro, Jonathan J. ^{[1
,2
,9
]}

Cahn, Jonathan ^{[1
]}

Lynn, Jason ^{[1
]}

Kim, Hyun-Soo ^{[1
]}

Berube, Benjamin ^{[1
,4
]}

Major, Viktoria ^{[5
]}

Calarco, Joseph P. ^{[1
,4
]}

Leblanc, Chantal ^{[1
]}

Bhattacharjee, Sonali ^{[1
]}

Ramu, Umamaheswari ^{[1
]}

Grimanelli, Daniel ^{[6
]}

Jacob, Yannick ^{[1
,7
]}

Voigt, Philipp ^{[8
]}

Joshua-Tor, Leemor ^{[1
,2
]}

Martienssen, Robert A. ^{[1
]}

机构：

[1] Howard Hughes Med Inst, Cold Spring Harbor Lab, 1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA

[2] Howard Hughes Med Inst, WM Keck Struct Biol Lab, Cold Spring Harbor, NY 10065 USA

[3] SUNY Stony Brook, Grad Program Genet, Stony Brook, NY 11794 USA

[4] Cold Spring Harbor Lab, Sch Biol Sci, 1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA

[5] Univ Edinburgh, Wellcome Ctr Cell Biol, Sch Biol Sci, Edinburgh EH9 3BF, Scotland

[6] Inst Rech Dev, 911 Ave Agropolis, F-34394 Montpellier, France

[7] Yale Univ, Fac Arts & Sci, Dept Mol Cellular & Dev Biol, 260 Whitney Ave, New Haven, CT 06511 USA

[8] Babraham Inst, Epigenet Programme, Cambridge CB22 3AT, England

[9] Atavistik Bio, Cambridge, MA USA

来源：

CELL | 2023年 / 186卷 / 19期

基金：

英国惠康基金; 美国国家科学基金会; 美国国家卫生研究院;

关键词：

TRANSPOSABLE ELEMENTS; FAMILY-MEMBER; SNF2; FAMILY; ARABIDOPSIS; LSH; HETEROCHROMATIN; PROTEIN; MAINTENANCE; DEPOSITION; DNMT1;

D O I：

10.1016/j.cell.2023.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleosomes block access to DNA methyltransferase, unless they are remodeled by DECREASE in DNA METHYLATION 1 (DDM1LSH/HELLS), a Snf2-like master regulator of epigenetic inheritance. We show that DDM1 promotes replacement of histone variant H3.3 by H3.1. In ddm1 mutants, DNA methylation is partly restored by loss of the H3.3 chaperone HIRA, while the H3.1 chaperone CAF-1 becomes essential. The single-particle cryo-EM structure at 3.2 A of DDM1 with a variant nucleosome reveals engagement with histone H3.3 near residues required for assembly and with the unmodified H4 tail. An N-terminal autoinhibitory domain inhibits activity, while a disulfide bond in the helicase domain supports activity. DDM1 co-localizes with H3.1 and H3.3 during the cell cycle, and with the DNA methyltransferase MET1Dnmt1, but is blocked by H4K16 acetylation. The male germline H3.3 variant MGH3/HTR10 is resistant to remodeling by DDM1 and acts as a placeholder nucleosome in sperm cells for epigenetic inheritance.

引用

页码：4100 / 4116.e15

页数：33

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