Regulation of cancer stem cells and immunotherapy of glioblastoma (Review)

被引：6

作者：

Kosianova, Aleksandra ^{[1
]}

Pak, Oleg ^{[1
]}

Bryukhovetskiy, Igor ^{[1
,2
]}

机构：

[1] Far Eastern Fed Univ, Med Ctr, Sch Med & Life Sci, Vladivostok 690091, Russia

[2] Far Eastern Fed Univ, Med Ctr, Sch Med & Life Sci, 10 Ajax Bay, Vladivostok 690091, Russia

来源：

BIOMEDICAL REPORTS | 2024年 / 20卷 / 02期

关键词：

glioblastoma; cancer stem cells; beta-catenin; targeted therapy; microenvironment; immunotherapy; RECURRENT GLIOBLASTOMA; WNT/BETA-CATENIN; PHASE-II; DOUBLE-BLIND; SURVIVAL; BRAIN; TEMOZOLOMIDE; BEVACIZUMAB; REOPERATION; RADIATION;

D O I：

10.3892/br.2023.1712

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glioblastoma (GB) is one of the most adverse diagnoses in oncology. Complex current treatment results in a median survival of 15 months. Resistance to treatment is associated with the presence of cancer stem cells (CSCs). The present review aimed to analyze the mechanisms of CSC plasticity, showing the particular role of beta-catenin in regulating vital functions of CSCs, and to describe the molecular mechanisms of Wnt-independent increase of beta-catenin levels, which is influenced by the local microenvironment of CSCs. The present review also analyzed the reasons for the low effectiveness of using medication in the regulation of CSCs, and proposed the development of immunotherapy scenarios with tumor cell vaccines, containing heterogenous cancer cells able of producing a multidirectional antineoplastic immune response. Additionally, the possibility of managing lymphopenia by transplanting hematopoietic stem cells from a healthy sibling and using clofazimine or other repurposed drugs that reduce beta-catenin concentration in CSCs was discussed in the present study.

引用

页数：17

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