Sarcoidosis-related autoimmune inflammation in COVID-19 convalescent patients

被引：3

作者：

Rubinstein, Artem ^{[1
,2
]}

Kudryavtsev, Igor ^{[1
,2
,3
]}

Malkova, Anna ^{[4
]}

Mammedova, Jennet ^{[2
]}

Isakov, Dmitry ^{[5
]}

Isakova-Sivak, Irina ^{[2
]}

Kudlay, Dmitry ^{[6
,7
,8
]}

Starshinova, Anna ^{[1
]}

机构：

[1] Almazov Natl Med Res Ctr, St Petersburg, Russia

[2] Inst Expt Med, St Petersburg, Russia

[3] Far Eastern Fed Univ, Vladivostok, Russia

[4] Ariel Univ, Fac Nat Sci, IL-40700 Ariel, Israel

[5] First St Petersburg State I Pavlov Med Univ, St Petersburg, Russia

[6] Sechenov Univ, IM Sechenov Moscow State Med Univ 1, Inst Pharm, Dept Pharmacol, Moscow, Russia

[7] NRC Inst Immunol, Moscow, Russia

[8] Fac Fundamental Med, Dept Pharmacognosy, Ind Pharm, Moscow, Russia

来源：

FRONTIERS IN MEDICINE | 2023年 / 10卷

关键词：

autoimmunity; sarcoidosis; COVID-19; post-COVID-19; syndrome; B-cell; follicular Th; follicular Treg; autoantibodies; FOLLICULAR REGULATORY T; B-CELLS; PULMONARY SARCOIDOSIS; HELPER-CELLS; BAFF; ANTIBODIES; AUTOANTIBODIES; ASSOCIATION; GRANULOMAS; RESPONSES;

D O I：

10.3389/fmed.2023.1271198

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Currently, there are a large number of reports about the development of autoimmune conditions after COVID-19. Also, there have been cases of sarcoid-like granulomas in convalescents as a part of the post-COVID-19 syndrome. Since one of the etiological theories of sarcoidosis considers it to be an autoimmune disease, we decided to study changes in the adaptive humoral immune response in sarcoidosis and SARS-CoV-2 infection and to find out whether COVID-19 can provoke the development of sarcoidosis. This review discusses histological changes in lymphoid organs in sarcoidosis and COVID-19, changes in B cell subpopulations, T-follicular helper cells (Tfh), and T-follicular regulatory cells (Tfr), and analyzes various autoantibodies detected in these pathologies. Based on the data studied, we concluded that SARS-CoV-2 infection may cause the development of autoimmune pathologies, in particular contributing to the onset of sarcoidosis in convalescents.

引用

页数：16

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