Fecal Microbiota Transplantation in Liver Cirrhosis

被引:26
作者
Boicean, Adrian [1 ,2 ]
Birlutiu, Victoria [1 ,2 ]
Ichim, Cristian [1 ,2 ]
Brusnic, Olga [3 ]
Onisor, Danusia Maria [3 ]
机构
[1] Cty Clin Emergency Hosp Sibiu, Sibiu 550245, Romania
[2] Lucian Blaga Univ Sibiu, Fac Med, Sibiu 550169, Romania
[3] Univ Med Pharm Sci & Technol Targu Mures, Dept Gastroenterol, Targu Mures 540142, Romania
关键词
fecal microbiota transplantation; microbiota; liver cirrhosis; microbiota transfer; CLOSTRIDIUM-DIFFICILE INFECTION; GUT MICROBIOTA; HEPATIC-ENCEPHALOPATHY; DISEASE; DONOR; PATHOGENESIS; DYSBIOSIS; MODULATION; CURCUMIN; THERAPY;
D O I
10.3390/biomedicines11112930
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The human gastrointestinal tract houses a diverse array of probiotic and pathogenic bacteria and any alterations in this microbial composition can exert a significant influence on an individual's well-being. It is well-established that imbalances in the gut microbiota play a pivotal role in the development of liver diseases. In light of this, a new adjuvant therapy for liver diseases could be regulating the intestinal microbiota. Through fecal microbiota transplantation, patients whose microbiomes are compromised are treated with stool from healthy donors in an attempt to restore a normal microbiome and alleviate their symptoms. A review of cross-sectional studies and case reports suggests that fecal microbiota transplants may offer effective treatment for chronic liver diseases. Adding to the potential of this emerging therapy, recent research has indicated that fecal microbiota transplantation holds promise as a therapeutic approach specifically for liver cirrhosis. By introducing a diverse range of beneficial microorganisms into the gut, this innovative treatment aims to address the microbial imbalances often observed in cirrhotic patients. While further validation is still required, these preliminary findings highlight the potential impact of fecal microbiota transplantation as a novel and targeted method for managing liver cirrhosis. We aimed to summarize the current state of understanding regarding this procedure, as a new therapeutic method for liver cirrhosis, as well as to explain its clinical application and future potential.
引用
收藏
页数:15
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