Molybdenum-Catalyzed Regio- and Enantioselective Amination of Allylic Carbonates: Total Synthesis of (S)-Clopidogrel

被引：11

作者：

Khan, Shahid ^{[1
,2
]}

Zhang, Junjie ^{[1
,2
]}

Khan, Ajmal ^{[1
,2
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Chem, Dept Chem, Xian 710049, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Shaanxi, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 26卷 / 14期

关键词：

BOND FORMATION; COMPLEXES; SUBSTITUTION; ALKYLATION;

D O I：

10.1021/acs.orglett.3c01641

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first molybdenum-catalyzed highlyregio- and enantioselectiveallylic amination of both aryl- and alkyl-substituted branched allyliccarbonates has been developed. A wide variety of amines, includingdrugs and complex bioactive molecules, underwent successful aminationwith excellent reaction outcomes (up to 96% yield, >99% ee, and>20:1b/l). The reaction could be scaled up and has been applied to thetotal synthesis of chiral drug molecule (S)-clopidogrel(Plavix).

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收藏

页码：2758 / 2762

页数：5

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