Extracellular vesicles: a rising star for therapeutics and drug delivery

被引：133
作者：
Du, Shuang [1 ]
Guan, Yucheng [1 ]
Xie, Aihua [1 ]
Yan, Zhao [1 ]
Gao, Sijia [2 ]
Li, Weirong [1 ]
Rao, Lang [3 ]
Chen, Xiaojia [2 ]
Chen, Tongkai [1 ]
机构：
[1] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, 12 Jichang Rd, Guangzhou 510405, Peoples R China
[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Room 6007,N22, Taipa 999078, Macau, Peoples R China
[3] Inst Biomed Hlth Technol & Engn, Shenzhen Bay Lab, Shenzhen 518132, Peoples R China
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2023年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Extracellular vesicles; Drug loading; Surface modification; Targeted therapy; Neurodegenerative diseases; Clinical challenges; FIELD-FLOW FRACTIONATION; LIQUID-CHROMATOGRAPHY; LOADED EXOSOMES; ENGINEERED EXOSOMES; PROSTATE-CANCER; NEXT-GENERATION; MOUSE MODEL; STEM-CELLS; HIGH-YIELD; PLASMA;
D O I：
10.1186/s12951-023-01973-5
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood-brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs.
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页数：51
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