Palladium-Catalyzed Annulative Coupling of Spirovinylcyclopropyl Oxindoles with p-Quinone Methides

被引：10

作者：

Debnath, Bijoy ^{[1
]}

Sarkar, Tanumay ^{[1
]}

Karjee, Pallab ^{[1
]}

Purkayastha, Siddhartha K. ^{[2
]}

Guha, Ankur K. ^{[3
]}

Punniyamurthy, Tharmalingam ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

[2] Assam Don Bosco Univ, Dept Chem, Sonapur 782402, India

[3] Cotton Univ, Adv Computat Chem Ctr, Gauhati 781001, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 14期

关键词：

1,6-CONJUGATE ADDITION; VINYL CYCLOPROPANES; ACCESS; CYCLOADDITION; AZIRIDINES; SPIROCYCLOPROPANATION; CYCLOPENTANES; CONSTRUCTION; REACTIVITY; ALKALOIDS;

D O I：

10.1021/acs.joc.3c00173

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd-catalyzed annulative coupling of spirovinylcyclopropyloxindoleswith p-quinone methides has been accomplished via cascade carbon-carbon bond formation to afford bis-spirooxindole scaffolds. The mild reaction conditions,diastereoselectivity, functional group diversity, post-synthetic transformations,and mechanistic studies using DFT calculations are the important practicalfeatures.

引用

页码：9704 / 9719

页数：16

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