NIR-II Imaging-Guided Mitochondrial-Targeting Organic Nanoparticles for Multimodal Synergistic Tumor Therapy

被引:34
作者
Yang, Sha [1 ,2 ,3 ,4 ]
Sun, Bin [5 ]
Liu, Fen [1 ]
Li, Na [1 ]
Wang, Minghui [1 ]
Wu, Peixian [1 ]
Wu, Gui-long [1 ]
Fang, Huilong [2 ,3 ,4 ]
He, Yuxuan [1 ]
Zhou, Wei [1 ]
Xiao, Hao [1 ]
Tan, Xiaofeng [1 ]
Tang, Li [1 ,6 ]
Zhu, Shoujun [5 ]
Yang, Qinglai [1 ]
机构
[1] Univ South China, Canc Res Inst, Ctr Mol Imaging Probe, Hengyang Med Sch,Hunan Prov Key Lab Tumor Cellular, Hengyang 421001, Hunan, Peoples R China
[2] Xiangnan Univ, Tumor Pathol Res Grp, Chenzhou 423000, Hunan, Peoples R China
[3] Xiangnan Univ, Dept Pathol, Inst Basic Dis Sci, Chenzhou 423000, Hunan, Peoples R China
[4] Xiangnan Univ, Sch Basic Med Sci, Chenzhou 423000, Hunan, Peoples R China
[5] Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China
[6] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Plant Chem, Minist Educ, Haikou 571158, Hainan, Peoples R China
基金
美国国家科学基金会;
关键词
immune therapy; mitochondrial-targeting; near-infrared (NIR)-II imaging-guided; photodynamic therapy; photothermal therapy; PHOTOSENSITIZER;
D O I
10.1002/smll.202207995
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Effectively interfering energy metabolism in tumor cells and simultaneously activating the in vivo immune system to perform immune attacks are meaningful for tumor treatment. However, precisely targeted therapy is still a huge challenge. Herein, a mitochondrial-targeting phototheranostic system, FE-T nanoparticles (FE-T NPs) are developed to damage mitochondria in tumor cells and change the tumor immunosuppressive microenvironment. FE-T NPs are engineered by encapsulating the near-infrared (NIR) absorbed photosensitizer IR-FE-TPP within amphiphilic copolymer DSPE-SS-PEG-COOH for high-performing with simultaneous mitochondrial-targeting, near-infrared II (NIR-II) fluorescence imaging, and synchronous photothermal therapy (PTT) /photodynamic therapy (PDT) /immune therapy (IMT). In tumor treatment, the disulfide in the copolymer can be cleaved by excess intracellular glutathione (GSH) to release IR-FE-TPP and accumulate in mitochondria. After 808 nm irradiation, the mitochondrial localization of FE-T NPs generated reactive oxygen species (ROS), and hyperthermia, leading to mitochondrial dysfunction, photoinductive apoptosis, and immunogenic cell death (ICD). Notably, in situ enhanced PDT/PTT in vivo via mitochondrial-targeting with FE-T NPs boosts highly efficient ICD toward excellent antitumor immune response. FE-T NPs provide an effective mitochondrial-targeting phototheranostic nanoplatform for imaging-guided tumor therapy.
引用
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页数:14
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