Role of skin management in the prevention of atopic dermatitis and food allergy

被引：8

作者：

Tham, Elizabeth Huiwen ^{[1
,2
,3
,8
]}

Yamamoto-Hanada, Kiwako ^{[4
,5
]}

Leung, Agnes Sze Yin ^{[6
,7
]}

Ohya, Yukihiro ^{[4
,5
]}

机构：

[1] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore

[2] Natl Univ Hlth Syst NUHS, Khoo Teck Puat Natl Univ Childrens Med Inst, Singapore, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore City, Singapore

[4] Natl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo, Japan

[5] Natl Ctr Child Hlth & Dev, Med Support Ctr Japan Environm & Childrens Study J, Tokyo, Japan

[6] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Paediat, Hong Kong, Peoples R China

[7] Chinese Univ Hong Kong, Hong Kong Hub Paediat Excellence, Hong Kong, Peoples R China

[8] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Div Allergy Immunol & Rheumatol, 1E Kent Ridge Rd, NUHS Tower Block Level 12, Singapore 119228, Singapore

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 2024年 / 35卷 / 03期

基金：

英国医学研究理事会;

关键词：

atopic dermatitis; eczema; food allergy; prevention; skin barrier; treatment; PEANUT CONSUMPTION; PROACTIVE THERAPY; RANDOMIZED-TRIAL; RISK; BARRIER; SENSITIZATION; EMOLLIENT; INFANTS; COLONIZATION; ASSOCIATION;

D O I：

10.1111/pai.14094

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Food allergy is postulated to originate from cutaneous sensitization through a disrupted skin barrier, particularly in atopic dermatitis (AD). Strategies for food allergy prevention currently centre around early allergic food introduction, but there is now increasing evidence for the role of early skin barrier restoration in the form of prophylactic emollient therapy and early aggressive, proactive treatment of established AD for food allergy prevention. Research gaps that remain to be addressed include the type of emollient or anti-inflammatory medication, which confers the greatest efficacy in preventive or proactive skin treatment, respectively, the duration of therapy, and the window of opportunity for these interventions. image

引用

页数：11