When after radical prostatectomy radiotherapy should be performed? Comparison of adjuvant and salvage radiotherapy (literature review)

被引：0

作者：

Taraki, I. A. ^{[1
,2
]}

Khmelevskiy, E. V. ^{[1
]}

Gaas, M. Ya. ^{[2
]}

Vorobyev, N. V. ^{[1
,3
]}

Sozykin, M. A. ^{[4
]}

机构：

[1] Minist Hlth Russia, Hertzen Moscow Oncol Res Inst, Branch Natl Med Res Radiol Ctr, 3 2nd Botkinskiy Proezd, Moscow 125284, Russia

[2] Peoples Friendship Univ Russia, 6 Miklukho Maklaya St, Moscow 117198, Russia

[3] IM Sechenov First Moscow State Med Univ, Minist Hlth RussiaI, 8 Trubetskaya St, Moscow 119991, Russia

[4] Pirogov Russian Natl Res Med Univ, NI Minist Hlth Russia, 1 Ostrovityanova St, Moscow 117997, Russia

来源：

ONKOUROLOGIYA | 2023年 / 19卷 / 04期

关键词：

radiotherapy; radical prostatectomy; adjuvant therapy; salvage therapy; recurrence; RADIATION-THERAPY; CANCER; PHASE-3; BENEFITS; TRIAL; RISK; MEN;

D O I：

10.17650/1726-9776-2023-19-4-139-147

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The question of optimal times and indications for radiotherapy (adjuvant or salvage) after surgical treatment of prostate cancer remains unanswered. Therefore, studies of this problem are essential and important for clinical practice. The article evaluates the effectiveness of adjuvant radiotherapy compared to salvage radiotherapy in the context of recurrence-free survival and associated adverse events. In 3 randomized clinical trials and meta-analysis, adjuvant radiotherapy did not show improved recurrence-free survival compared to salvage radiotherapy. The choice between adjuvant and salvage radiotherapy should be based on individual patient history and the risk of recurrence. Delayed radiotherapy can help some patients to avoid excessive treatment and associated adverse events.

引用

页码：139 / 147

页数：9

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