Invasive aspergillosis in adult patients in Australia and New Zealand: 2017-2020

被引：8

作者：

Tio, Shio Yen ^{[1
,2
,3
,4
]}

Chen, Sharon C. -A. ^{[5
]}

Hamilton, Kate ^{[5
]}

Heath, Christopher H. ^{[6
,7
,8
]}

Pradhan, Alyssa ^{[9
,10
]}

Morris, Arthur J. ^{[11
]}

Korman, Tony M. ^{[12
,13
]}

Morrissey, Orla ^{[14
,15
]}

Halliday, Catriona L. ^{[5
,10
]}

Kidd, Sarah ^{[16
]}

Spelman, Timothy ^{[17
,18
]}

Brell, Nadiya ^{[19
]}

McMullan, Brendan ^{[20
,21
]}

Clark, Julia E. ^{[22
,23
]}

Mitsakos, Katerina ^{[24
]}

Hardiman, Robyn P. ^{[24
]}

Williams, Phoebe ^{[20
,25
]}

Campbell, Anita J. ^{[26
,27
]}

Beardsley, Justin ^{[28
,29
,30
]}

Van Hal, Sebastiaan ^{[10
,31
]}

Yong, Michelle K. ^{[1
,2
,3
,4
]}

Worth, Leon J. ^{[1
,2
,4
]}

Slavin, Monica A. ^{[1
,2
,3
,4
]}

机构：

[1] Peter MacCallum Canc Ctr, Dept Infect Dis, 305 Grattan St, Melbourne, Vic 3000, Australia

[2] Natl Ctr Infect Canc, Melbourne, Australia

[3] Royal Melbourne Hosp, Dept Infect Dis, Melbourne, Australia

[4] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[5] Westmead Hosp, Inst Clin Pathol & Med Res, New South Wales Hlth Pathol, Ctr Infect Dis & Microbiol Lab Serv, Sydney, Australia

[6] PathWest Lab Med, Dept Microbiol, Murdoch, WA, Australia

[7] Fiona Stanley Hosp, Dept Infect Dis, Murdoch, WA, Australia

[8] Univ Western Australia, Dept Med, Crawley, WA, Australia

[9] Prince Wales Hosp, Southeast Sydney LHD, NSW Hlth Pathol, Sydney, Australia

[10] Univ Sydney, Sch Med, Sydney, Australia

[11] Auckland City Hosp, 2 Pk Rd Grafton, Auckland 1023, New Zealand

[12] Monash Univ, Clayton, Vic, Australia

[13] Monash Hlth, Clayton, Vic, Australia

[14] Alfred Hlth, Dept Infect Dis, Melbourne, Vic, Australia

[15] Monash Univ, Melbourne, Vic, Australia

[16] SA Pathol, Microbiol & Infect Dis, Natl Mycol Reference Ctr, Adelaide, SA, Australia

[17] Peter MacCallum Canc Ctr, Dept Hlth Serv Res, Melbourne, Australia

[18] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[19] Univ New South Wales, Sydney, NSW, Australia

[20] Sydney Childrens Hosp, Dept Immunol & Infect Dis, Randwick, NSW, Australia

[21] UNSW, Fac Med & Hlth, Sch Clin Med, Sydney, NSW, Australia

[22] Childrens Hlth Queensland, Queensland Childrens Hosp, Infect Management Serv, Brisbane 4101, Australia

[23] Univ Queensland, Sch Clin Med, CHQCU, Brisbane, Australia

[24] Royal North Shore Hosp, Dept Infect Dis & Microbiol, Sydney, Australia

[25] Univ Sydney, Fac Med, Sch Publ Hlth, Sydney, Australia

[26] Perth Childrens Hosp, Dept Infect Dis, Perth, WA, Australia

[27] Univ Western Australia, Telethon Kids Inst, Wesfarmers Ctr Vaccines & Infect Dis, Perth, WA, Australia

[28] Univ Sydney, Infect Dis Inst, Sydney, Australia

[29] NSW Hlth, Westmead Hosp, Western Sydney LHD, Westmead, NSW, Australia

[30] Westmead Inst Med Res, Westmead, NSW, Australia

[31] Royal Prince Alfred Hosp, Dept Infect Dis & Microbiol, Camperdown, NSW, Australia

来源：

LANCET REGIONAL HEALTH-WESTERN PACIFIC | 2023年 / 40卷

基金：

英国医学研究理事会;

关键词：

Invasive aspergillosis; Epidemiology; Outcome; Australasia; ACUTE MYELOID-LEUKEMIA; PULMONARY ASPERGILLOSIS; ANTIFUNGAL RESISTANCE; FILAMENTOUS-FUNGI; AMPHOTERICIN-B; PCR ASSAY; INFECTIONS; IDENTIFICATION; CANDIDA; DETECT;

D O I：

10.1016/j.lanwpc.2023.100888

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background New and emerging risks for invasive aspergillosis (IA) bring the need for contemporary analyses of the epidemiology and outcomes of IA, in order to improve clinical practice.Methods The study was a retrospective, multicenter, cohort design of proven and probable IA in adults from 10 Australasian tertiary centres (January 2017-December 2020). Descriptive analyses were used to report patients' demographics, predisposing factors, mycological characteristics, diagnosis and management. Accelerated failure-time model was employed to determine factor(s) associated with 90-day all-cause mortality (ACM).Findings Of 382 IA episodes, 221 (in 221 patients) fulfilled inclusion criteria - 53 proven and 168 probable IA. Median patient age was 61 years (IQR 51-69). Patients with haematologic malignancies (HM) comprised 49.8% of cases. Fifteen patients (6.8%) had no pre-specified immunosuppression and eleven patients (5.0%) had no documented comorbidity. Only 30% of patients had neutropenia. Of 170 isolates identified, 40 (23.5%) were identified as non-Aspergillus fumigatus species complex. Azole-resistance was present in 3/46 (6.5%) of A. fumigatus sensu stricto isolates. Ninety-day ACM was 30.3%. HM (HR 1.90; 95% CI 1.04-3.46, p = 0.036) and ICU admission (HR 4.89; 95% CI 2.93-8.17, p < 0.001) but not neutropenia (HR 1.45; 95% CI 0.88-2.39, p = 0.135) were associated with mortality. Chronic kidney disease was also a significant predictor of death in the HM subgroup (HR 3.94; 95% CI 1.15-13.44, p = 0.028).Interpretation IA is identified in high number of patients with mild/no immunosuppression in our study. The relatively high proportion of non -A. fumigatus species complex isolates and 6.5% azole-resistance rate amongst A. fumigatus sensu stricto necessitates accurate species identification and susceptibility testing for optimal patient outcomes.Copyright (c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：14

共 44 条

[21] The Outcomes of Patients with ESRD and ANCA-Associated Vasculitis in Australia and New Zealand
Tang, Wen
Bose, Bhadran
McDonald, Stephen P.
Hawley, Carmel M.
Badve, Sunil V.
Boudville, Neil
Brown, Fiona G.
Clayton, Philip A.
Campbell, Scott B.
Peh, Chen Au
Johnson, David W.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 8 (05): : 773 - 780
[22] In vitro activity of ceftolozane/tazobactam against multidrug-resistant Pseudomonas aeruginosa from patients in Western Europe: SMART 2017-2020
Karlowsky, James A.
Lob, Sibylle H.
Siddiqui, Fakhar
Akrich, Brune
DeRyke, C. Andrew
Young, Katherine
Motyl, Mary R.
Hawser, Stephen P.
Sahm, Daniel F.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023, 61 (05)
[23] Comparison of galactomannan, beta-D-glucan, and Aspergillus DNA in sera of high-risk adult patients with hematological malignancies for the diagnosis of invasive aspergillosis
Boluk, Gulcin
Kazak, Esra
Ozkalemkas, Fahir
Ener, Beyza
Akalin, Halis
Agca, Harun
Okuturlar, Yildiz
Keskin, Kursad
Burgazlioglu, Basak
Ali, Ridvan
TURKISH JOURNAL OF MEDICAL SCIENCES, 2016, 46 (02) : 335 - 342
[24] Characteristics and outcome of patients with the ICU Admission diagnosis of status epilepticus in Australia and New Zealand
Hay, Alison
Bellomo, Rinaldo
Pilcher, David
Jackson, Graeme
Kaukonen, Kirsi-Majia
Bailey, Michael
JOURNAL OF CRITICAL CARE, 2016, 34 : 146 - 153
[25] Correlation between high-resolution computed tomography and galactomannan antigenemia in adult hematologic patients at risk for invasive aspergillosis
Hidalgo, A.
Parody, R.
Martino, R.
Sanchez, F.
Franquet, T.
Gimenez, A.
Blancas, C.
EUROPEAN JOURNAL OF RADIOLOGY, 2009, 71 (01) : 55 - 60
[26] Impact of revised EORTC/MSGERC 2020 criteria on diagnosis and prognosis of invasive pulmonary aspergillosis in patients with hematological malignancies undergoing bronchoscopy
Acet-Ozturk, N. A.
Omer-Topcu, D.
Vurat-Acar, K.
Aydin-Guclu, O.
Pinar, I. E.
Demirdogen, E.
Gorek-Dilektasli, A.
Kazak, E.
Ozkocaman, V
Ursavas, A.
Akalin, H.
Ozkalemkas, F.
Ener, B.
Ali, R.
JOURNAL DE MYCOLOGIE MEDICALE, 2022, 32 (04):
[27] Antibody specific to thioredoxin reductase as a new biomarker for serodiagnosis of invasive aspergillosis in non-neutropenic patients
Shi, Li-ning
Li, Fang-qiu
Lu, Jing-fen
Kong, Xiao-xiang
Wang, Shi-qin
Huang, Mei
Shao, Hai-feng
Shao, Shi-he
CLINICA CHIMICA ACTA, 2012, 413 (9-10) : 938 - 943
[28] Performance of Existing Definitions and Tests for the Diagnosis of Invasive Fungal Diseases other than Invasive Candidiasis and Invasive Aspergillosis in Critically Ill, Adult Patients: A Systematic Review with Qualitative Evidence Synthesis
Giacobbe, Daniele R.
Cortegiani, Andrea
Karaiskos, Ilias
Mercier, Toine
Tejada, Sofia
Peghin, Maddalena
Grecchi, Cecilia
Rebuffi, Chiara
Asperges, Erika
Zuccaro, Valentina
Scudeller, Luigia
Bassetti, Matteo
JOURNAL OF FUNGI, 2021, 7 (03) : 1 - 9
[29] Risk factors for invasive aspergillosis in ICU patients with COVID-19: current insights and new key elements
Montrucchio, G.
Lupia, T.
Lombardo, D.
Stroffolini, G.
Corcione, S.
De Rosa, F. G.
Brazzi, L.
ANNALS OF INTENSIVE CARE, 2021, 11 (01)
[30] Annual prevalence, characteristics, and outcomes of intensive care patients with skin or soft tissue infections in Australia and New Zealand: A retrospective cohort study between 2006-2017
Bekker, Marjolein A.
Rai, Sumeet
Arbous, M. Sesmu
Georgousopoulou, Ekavi N.
V. Pilcher, David
Haren, Frank M. P. van
AUSTRALIAN CRITICAL CARE, 2021, 34 (05) : 403 - 410

← 1 2 3 4 5 →