Ivermectin and moxidectin against soil-transmitted helminth infections

被引：14
作者：
Hurlimann, Eveline [1 ,2 ]
Hofmann, Daniela [1 ,2 ]
Keiser, Jennifer [1 ,2 ]
机构：
[1] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Allschwil, Switzerland
[2] Univ Basel, Basel, Switzerland
来源：
TRENDS IN PARASITOLOGY | 2023年 / 39卷 / 04期
基金：
瑞士国家科学基金会;
关键词：
STRONGYLOIDES-STERCORALIS INFECTIONS; TRICHURIS-TRICHIURA; PHARMACOKINETICS; SAFETY; EFFICACY; ALBENDAZOLE; TOLERABILITY; BIOAVAILABILITY; ONCHOCERCIASIS; AVERMECTINS;
D O I：
10.1016/j.pt.2023.01.009
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Ivermectin and moxidectin, two macrocyclic lactones, are potent antiparasitic drugs currently registered and mainly used against filarial diseases; however, their potential value for improved soil-transmitted helminth (STH) control has been acknowledged. This review provides insights on recent studies evaluating the efficacy of ivermectin and moxidectin as single or coadministered therapy against human soil-transmitted helminthiases (including Strongyloides stercoralis infections) and on pharmacokinetic/pharmacodynamic parameters measured in treated populations. Furthermore, we discuss current gaps for research, highlight advantages - but also existing challenges - for uptake of ivermectin and/or moxidectin treatment schemes into routine STH control in endemic countries.
引用
收藏
页码：272 / 284
页数：13
相关论文
共 90 条
[41]   Broadening the range of use cases for ivermectin - a review of the evidence [J].
Kositz, Christian ;
Bradley, John ;
Hutchins, Harry ;
Last, Anna ;
D'Alessandro, Umberto ;
Marks, Michael .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2022, 116 (03) :201-212
[42]  
KRISHNA DR, 1993, ARZNEIMITTEL-FORSCH, V43-1, P609
[43]  
Krolewiecki Alejandro, 2022, Gates Open Res, V6, P62, DOI 10.12688/gatesopenres.13615.1
[44]   A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full [J].
Krolewiecki, Alejandro J. ;
Lammie, Patrick ;
Jacobson, Julie ;
Gabrielli, Albis-Francesco ;
Levecke, Bruno ;
Socias, Eugenia ;
Arias, Luis M. ;
Sosa, Nicanor ;
Abraham, David ;
Cimino, Ruben ;
Echazu, Adriana ;
Crudo, Favio ;
Vercruysse, Jozef ;
Albonico, Marco .
PLOS NEGLECTED TROPICAL DISEASES, 2013, 7 (05)
[45]  
Long QC., 2001, J Clin Pharmacol, V17, P203
[46]   Impact of annual and semi-annual mass drug administration for Lymphatic Filariasis and Onchocerciasis on Hookworm Infection in Cote d'Ivoire [J].
Loukouri, Agodio ;
Meite, Aboulaye ;
Koudou, Benjamin G. ;
Goss, Charles W. ;
Lew, Daphne ;
Weil, Gary J. ;
N'Goran, Eliezer K. ;
Fischer, Peter U. .
PLOS NEGLECTED TROPICAL DISEASES, 2020, 14 (09) :1-15
[47]   Strongyloides hyperinfection syndrome:: an emerging global infectious disease [J].
Marcos, Luis A. ;
Terashima, Angelica ;
DuPont, Herbert L. ;
Gotuzzo, Eduardo .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2008, 102 (04) :314-318
[48]   Ivermectin: An Anthelmintic, an Insecticide, and Much More [J].
Martin, Richard J. ;
Robertson, Alan P. ;
Choudhary, Shivani .
TRENDS IN PARASITOLOGY, 2021, 37 (01) :48-64
[49]   Efficacy and Safety of Albendazole and High-Dose Ivermectin Coadministration in School-Aged Children Infected With Trichuris trichiura in Honduras: A Randomized Controlled Trial [J].
Matamoros, Gabriela ;
Sanchez, Ana ;
Gabrie, Jose Antonio ;
Juarez, Marisa ;
Ceballos, Laura ;
Escalada, Andres ;
Rodriguez, Carol ;
Marti-Soler, Helena ;
Rueda, Maria Mercedes ;
Canales, Maritza ;
Lanusse, Carlos ;
Cajal, Pamela ;
Alvarez, Luis ;
Cimino, Ruben O. ;
Krolewiecki, Alejandro .
CLINICAL INFECTIOUS DISEASES, 2021, 73 (07) :1203-1210
[50]   Moxidectin: an oral treatment for human onchocerciasis [J].
Milton, Philip ;
Hamley, Jonathan I. D. ;
Walker, Martin ;
Basanez, Maria-Gloria .
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2020, 18 (11) :1067-1081
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