Ivermectin and moxidectin against soil-transmitted helminth infections

被引：14
作者：
Hurlimann, Eveline [1 ,2 ]
Hofmann, Daniela [1 ,2 ]
Keiser, Jennifer [1 ,2 ]
机构：
[1] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Allschwil, Switzerland
[2] Univ Basel, Basel, Switzerland
来源：
TRENDS IN PARASITOLOGY | 2023年 / 39卷 / 04期
基金：
瑞士国家科学基金会;
关键词：
STRONGYLOIDES-STERCORALIS INFECTIONS; TRICHURIS-TRICHIURA; PHARMACOKINETICS; SAFETY; EFFICACY; ALBENDAZOLE; TOLERABILITY; BIOAVAILABILITY; ONCHOCERCIASIS; AVERMECTINS;
D O I：
10.1016/j.pt.2023.01.009
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Ivermectin and moxidectin, two macrocyclic lactones, are potent antiparasitic drugs currently registered and mainly used against filarial diseases; however, their potential value for improved soil-transmitted helminth (STH) control has been acknowledged. This review provides insights on recent studies evaluating the efficacy of ivermectin and moxidectin as single or coadministered therapy against human soil-transmitted helminthiases (including Strongyloides stercoralis infections) and on pharmacokinetic/pharmacodynamic parameters measured in treated populations. Furthermore, we discuss current gaps for research, highlight advantages - but also existing challenges - for uptake of ivermectin and/or moxidectin treatment schemes into routine STH control in endemic countries.
引用
收藏
页码：272 / 284
页数：13
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